Magnetic Resonance Imaging Development for High Resolution Atrial Structural and Functional Characterization
Launched by ASSISTANCE PUBLIQUE - HÔPITAUX DE PARIS · Sep 25, 2024
Trial Information
Current as of March 07, 2025
Not yet recruiting
Keywords
ClinConnect Summary
This Magnetic Resonance imaging study of the heart aims to acquire images and measures of:
1. Left atrial cine: compressed sensing cine imaging strategies will be tested for LA assessment by optimizing spatial and temporal resolution providing the best image quality relative to acceptable acquisition times. The whole heart should be covered during acquisition. Image quality and diagnosis of LA contraction preservation will be performed.
2. Myocardial tissue characterization including:
1. 3D isotropic ECG-gated with respiratory navigation late gadolinium enhancement (LGE) sequence for h...
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- For all groups of AF patients:
- • Over 18 years of age
- • Participation to the MAESTRIA-AFNET 10 study
- • Able to undergo an injected MRI examination
- • Able to give consent
- • Affiliated to French social security system
- • Specific inclusion criteria of AF patients (same as MAESTRIA-AFNET 10) Group 1: patients with paroxysmal AF (no AF during exam) clinically defined as AF episodes less than one week Group 2: patients with persistent AF, clinically defined as AF episodes longer than one week Group 3: patients with permanent AF, with no documented sinus rhythm or possibility to restore sinus rhythm by any means
- For healthy volunteers (Group 4):
- • Over 18 years of age (including 30 subjects \< 60 years)
- • Able to undergo an MRI examination
- • Able to give consent
- • Affiliated to French social security system
- Exclusion Criteria:
- • For all groups
- • Deprived of liberty or under legal protection (under guardianship or curatorship)
- • Kidney disease with GFR \<30 mL / min (because of the risks linked to the injection of DOTAREM ™ and iodine)
- • Pregnant woman, breastfeeding, of childbearing age in the absence of effective contraception
- • MRI contraindication (claustrophobia, patients with metallic foreign bodies)
- • Participation to another interventional clinical trial (Jardé 1) For patients
- • Patients with a history of renal disease (renal transplant, single kidney, renal cancer)
- • Patients who have received a dose of contrast in the last 24 hours
- • Patients who had a previous allergic or anaphylactic reaction to gadolinium For volunteers
- • Subjects with known cardiovascular pathology or under cardiovascular treatment
- • Subjects with cardiovascular history
- • Subjects with cardiac rhythm or conduction disorders
About Assistance Publique Hôpitaux De Paris
Assistance Publique - Hôpitaux de Paris (AP-HP) is a leading public hospital system in France, renowned for its commitment to healthcare excellence and innovative medical research. As a prominent clinical trial sponsor, AP-HP plays a pivotal role in advancing medical knowledge and improving patient care through rigorous scientific investigations across a wide range of therapeutic areas. With a focus on collaboration and interdisciplinary approaches, AP-HP leverages its extensive network of hospitals and expert clinicians to facilitate high-quality clinical trials that adhere to the highest ethical and regulatory standards, ultimately aiming to translate research findings into tangible health benefits for diverse patient populations.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
People applied
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
Discussion 0
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