Dexmedetomidine in Reducing Postoperative Delirium in Cardiac Surgery Patients

Launched by XIJING HOSPITAL · Sep 28, 2024

Keywords

ClinConnect Summary

This clinical trial is studying whether a nasal spray called dexmedetomidine can help reduce the risk of delirium in patients undergoing cardiac surgery. Delirium is a common condition that can happen after surgery, often linked to poor sleep before the operation. The researchers believe that by improving sleep before surgery with dexmedetomidine, they can help lower the chances of patients experiencing delirium afterward.

To participate in this study, individuals need to be at least 18 years old and scheduled for cardiac surgery that involves a heart-lung machine. However, some people may not be eligible, including those with certain neurological conditions or serious heart issues. If someone joins the trial, they will receive the nasal spray before their surgery and will be monitored for any changes in their sleep and overall recovery. This study is currently looking for participants, and your involvement could help improve care for future cardiac surgery patients.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Aged 18 years or older.
• • 2. Cardiac surgery with cardiopulmonary bypass.
• • 3. Ability to provide consent.
• Exclusion Criteria:
• • 1. Preoperative schizophrenia, epilepsy, Parkinson's disease, myasthenia gravis, history of neurosurgery, or Mini-mental State Examination(MMSE) score: illiteracy\<17, primary school level\<20, high school level \<24.
• • 2. Patients with sick sinus syndrome, severe sinus bradycardia (heart rate\<50 beats/minute), grade II or above atrioventricular block, and no pacemaker implanted.
• • 3. Unable to communicate due to coma, severe dementia, or language barriers prior to surgery.
• • 4. Patients with severe liver dysfunction (Child Pugh C grade), renal dysfunction (preoperative dialysis), ASA grade V or expected survival ≤ 24 hours.
• • 5. Heart transplant surgery
• • 6. Surgery for congenital heart disease.
• • 7. Deep hypothermic circulatory arrest surgery.
• • 8. Already enrolled in other study patients.
• • 9. Refuse to participate.