Ex Vivo Drug Response Evaluation for Next Generation Care of Brain Metastases

Launched by UNIVERSITY OF ZURICH · Sep 27, 2024

Keywords

ClinConnect Summary

This clinical trial is studying a new way to personalize treatment for patients with brain metastases, which are cancers that have spread to the brain from other parts of the body. The trial will use a method called pharmacoscopy, which tests how cancer cells from a patient's tumor respond to different drugs in real-time. By doing this, researchers hope to find the most effective treatments tailored to each patient's specific cancer, especially when standard options are limited.

To join the trial, participants must be at least 18 years old and have a confirmed diagnosis of brain metastases that require surgery. They should have limited treatment options available, and their overall health must be stable enough for the study. Participants can expect to undergo surgery, from which researchers will take a sample of their tumor for testing. This trial is not yet recruiting, but it aims to provide valuable insights into more effective treatments for brain tumors, which could lead to better outcomes for patients facing this challenging condition.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients must be 18 years or older on the day of signing the informed consent, female or male.
• • Patients must have a Karnofsky performance status of 60 or more
• • Patients must have limited systemic therapeutic options as per treating physician judgement. The number of previous lines of therapies is not limited.
• • Patients with a tumor with a targetable oncogenic driver mutation should have already been treated with a targeted agent and options must have been exhausted.
• • Patients must have a clinical indication for surgery for probable brain metastasis
• • Patients will be considered eligible for the study only if the diagnosis of brain metastasis has been histologically confirmed on the sample obtained during the surgery performed after signing the informed consent form for the trial.
• • Any type of primary cancer is allowed: breast cancer, lung cancer, melanoma, other cancers. Patients may have several primary cancers.
• • Patients must have adequate bone marrow, renal and hepatic function documented at screening before surgery
• • Women of childbearing potential, including women who had their last menstruation in the last 2 years, must have a negative urinary or serum pregnancy test
• • Patients must have the ability to understand the requirements of the study, provide written informed consent and authorization of use and disclosure of protected health information, and agree to abide by the study restrictions and return for the required assessments.
• • Written informed consent for study participation must be signed and dated by the patient and the investigator prior to any study-related intervention.
• Exclusion Criteria:
• • Patients with rapidly progressive systemic disease
• • Patients with inability to undergo brain MRI evaluation.
• • Patients with progressive parenchymal brain metastases with an indication for requiring whole brain radiotherapy after surgery. Focal brain radiotherapy after surgery is allowed.
• • Judgement by the investigator that the patient is unlikely to comply with study procedures, restrictions and requirements.
• • Intention to become pregnant during the course of the study.
• • Female who are pregnant.
• • Female who are breastfeeding and who do not agree to discontinue nursing prior to the first treatment initiated during the study.
• • Sexually active males and females of childbearing potential who are not willing to use an effective contraceptive method during the study. Male participants who do not agree not to donate sperm.