Pre-operative Phentolamine Vs Intraoperative Esmolol Efficacy for Hypotensive Anesthesia in Functional Endoscopic Sinus Surgery

Launched by AIN SHAMS UNIVERSITY · Sep 29, 2024

Keywords

ClinConnect Summary

This clinical trial is studying two different medications, phentolamine and esmolol, to see which one is more effective in managing low blood pressure during a specific type of surgery called functional endoscopic sinus surgery. The goal is to find out how well each medication works in keeping patients stable and safe while they undergo this procedure.

To participate in the trial, individuals must be between the ages of 21 and 50 and in good health, rated as ASA physical status I or II, which means they have no serious medical issues affecting their ability to undergo anesthesia. However, people with certain health conditions, such as heart problems or those who have had previous surgeries on their nose, will not be eligible to join. If someone qualifies and chooses to participate, they can expect to receive one of the two medications during their surgery and have their blood pressure monitored closely to assess the effectiveness of the treatment. It's important to know that this trial is not yet recruiting participants, so anyone interested will need to wait until it officially begins.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age from 21 to 50 years.
• • Both sexes.
• • American Society of Anesthesiologists (ASA) physical status I-II.
• Exclusion Criteria:
• • Patients with a medical condition that contraindicated hypotensive anesthesia, such as peripheral vascular disease, cerebrovascular stroke, carotid artery stenosis, previous myocardial infarction, ischemic heart disease, congestive heart failure, limb ischemia, uncontrolled hypertension and raised intracranial tension
• • Renal disease, liver dysfunction, pregnancy.
• • Patients on hypnotic or narcotic analgesic.
• • History of alcohol or drug abuse.
• • History of allergic reaction to any drug used in this study.
• • Bleeding diathesis.
• • Previous nasal surgery.
• • Patients on Non-steroidal anti-inflammatory drugs (NSAIDs).
• • Patients with peripheral vascular disease.