Ventriculo-Arterial Coupling and Intra-Dialytic Changes in Hemodialysis Patients: Prognostic Insights

Launched by NAZARBAYEV UNIVERSITY · Sep 29, 2024

Keywords

ClinConnect Summary

This clinical trial is designed to study how hemodialysis (a treatment for kidney failure) affects the heart's function, specifically looking at the relationship between the heart and arteries. Researchers want to understand how changes in blood volume during dialysis sessions impact heart mechanics in patients with end-stage renal disease (ESRD). They will measure different heart and vascular parameters before and after dialysis to see if these measurements can help predict health outcomes, such as hospitalizations or heart-related issues, over an 18-month period.

To participate in this trial, individuals must be at least 18 years old and have been receiving regular dialysis for at least three months. They should also meet certain health criteria, such as having a specific level of dialysis adequacy. However, those with recent heart complications or other serious health conditions may not be eligible. Participants will undergo standard heart imaging tests before and after their dialysis sessions, and their health will be monitored throughout the study to gather valuable information about the heart's performance in relation to dialysis treatment.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 18 years or older;
• • Standard renal replacement schedule with 3 dialysis sessions per week;
• • Dialysis vintage of at least 3 months;
• • Dialysis adequacy with single-pool Kt/V \>1.2
• Exclusion Criteria:
• • Previous kidney transplantation
• • Myocardial infarction, unstable angina or stroke during the previous 6 months;
• • Severe stage III to IV congestive heart failure according to the NYHA classification;
• • Chronic atrial fibrillation or other known arrhythmia;
• • History of non-adherence to the prescribed weekly dialysis schedule in the previous month;
• • Body mass index \>40 Kg/m2; or
• • History of malignancy or other clinical conditions associated with very poor prognosis.