Circadian Mechanisms, Glucose, and CV Risks in T1D

Launched by UNIVERSITY OF ILLINOIS AT CHICAGO · Sep 30, 2024

Keywords

ClinConnect Summary

This clinical trial is looking at how improving sleep patterns may help people with type 1 diabetes (T1D) manage their blood sugar levels and reduce their risk of heart disease. Research shows that people with T1D often have sleep issues, and these problems can be linked to heart health. The study will involve participants working on stabilizing their sleep schedules to see how it affects their glucose control and cardiovascular health.

To join this study, you must be an adult aged 18 to 50 with a confirmed diagnosis of T1D for at least a year and experience irregular sleep patterns of more than an hour each week. You should also have a smartphone and be interested in improving your sleep. However, certain conditions like very high blood sugar levels, severe sleep problems, or certain medical histories may prevent you from participating. If you qualify, you'll have a chance to learn more about your sleep and health while contributing to important research.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Adults 18-50 years with a clinical diagnosis of T1D for at least one year
• • Report habitual sleep irregularity ≥1 hour/week
• • Desire to improve sleep, and own a smartphone (Android or iPhone)
• Exclusion Criteria:
• • Self-reported A1C within the past 6 months ≥10%
• • insomnia symptoms defined as Insomnia Severity Index score ≥15
• • history of restless leg syndrome
• • history of severe hypoglycemia (defined as hypoglycemic episode that results in loss of consciousness, seizure, or requiring emergency room visit or hospitalization) within the past 6 months
• • rotating shift or night work or routinely sleeping after 3 AM.
• • use of sleep medications/aids, significant medical comorbidities (such as heart failure, cirrhosis, chronic obstructive pulmonary disease requiring oxygen, active treatment for cancer, on renal replacement therapy \[dialysis\])
• • depression (Patient Health Questionnaire 8 \[PHQ-8\] score ≥15)
• • history of stroke with neurological deficits
• • pregnant, breast feeding, or planning pregnancy, as sleep and glucose are known to change during pregnancy and breastfeeding.
• • Allergy to lidocaine Participants who passed the first screen by phone will be scheduled for a consenting visit at UIC