Computer Game, Qualitative, and MEG/EEG Assessment of Serotonergic Psychedelics

Launched by YALE UNIVERSITY · Sep 30, 2024

Keywords

ClinConnect Summary

This clinical trial is studying how certain psychedelics, like psilocybin and LSD, affect the brain's ability to process information. The researchers want to understand if these substances help the brain focus on new information rather than old memories while someone is under their influence and for several weeks afterward. They are also interested in whether these psychedelics cause long-term changes in how people see, hear, and feel the world around them and how they adjust their beliefs. By comparing participants who take the psychedelics to those who receive a placebo (a harmless sugar pill), the study aims to pinpoint specific effects tied to the psychedelics.

To be eligible for the study, participants must be part of a clinical trial at Yale that involves these psychedelics and should not have any current psychotic symptoms. They will undergo a variety of assessments, such as online games and questionnaires, brain scans using MRI, and interviews about their experiences. This research could provide valuable insights into how psychedelics work in the brain and who may benefit from them, as well as identify potential side effects.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Participation in approved clinical protocol at Yale University involving potential administration of serotonergic psychedelics
• • Absence of pre-existing psychotic symptoms
• Exclusion Criteria:
• • Current intoxication based on self-report
• • Any neurological, medical or developmental problem that is known to impair cognition significantly based on self-report
• • History of seizures based on self-report
• • Contraindications for MR scanning including metallic implants of any kind, pacemakers and history of accidents with metal, claustrophobia (specific to those who will participate in MRI)