Effectiveness of SRP+ Lipo-curcumin Gel for the Treatment of Stage III Periodontitis.

Launched by G. D'ANNUNZIO UNIVERSITY · Sep 30, 2024

Keywords

ClinConnect Summary

This clinical trial is studying the effectiveness of a treatment for Stage III periodontitis, a serious gum disease that can lead to tooth loss. Researchers want to see if combining a standard cleaning method called Scaling and Root Planing (SRP) with a special gel containing lipo-curcumin (a natural compound) is more effective than SRP alone or with other gels. The trial will involve 40 patients, who will be divided into four groups: one group will receive the SRP with lipo-curcumin gel, while the other groups will receive SRP with different gels or just the SRP treatment.

To be eligible, participants must have Stage III periodontitis, be between the ages of 18 and 70, and not have certain health issues that could affect the results, like uncontrolled diabetes or recent antibiotic use. Throughout the 12-month study, patients will undergo regular check-ups to measure their gum health, including the depth of the pockets between the gums and teeth, to see how well the treatments are working. This trial is important because it could help improve the treatment options for those suffering from gum disease, possibly leading to better dental health outcomes.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients with a diagnosis of periodontitis stage III (grades A to C)
• • on-smokers or former smokers who quit at least 1 year ago, and had not received any periodontal treatment in the 3 months prior to recruitment
• • FMPS \< 20% at baseline
• • Furcation not involved
• • Not Pregnant or Lactating
• • Signed informed consent
• Exclusion Criteria:
• • Presence of uncontrolled systemic diseases that could affect treatment outcomes such as diabetes mellitus with an HbA1C\>7%, rheumatoid arthritis or any form of immunosuppression
• • Patients that had received systemic or local delivery of antibiotic therapy 6 weeks before enrollment
• • Chronic intake of NSAIDs or steroids, currently