Test of Reproducibility of [15O]H20-PET Assessment of Brain Perfusion

Launched by UNIVERSITY HOSPITAL BISPEBJERG AND FREDERIKSBERG · Sep 30, 2024

Keywords

ClinConnect Summary

This clinical trial is studying how well a special imaging test called [15O]H2O-PET can measure blood flow in the brain, particularly in older adults who may have small vessel disease (SVD) related to conditions like diabetes and dementia. Researchers want to understand how reduced blood flow in the brain and heart might affect thinking abilities and overall fitness in people with type 2 diabetes. The goal is to find better ways to diagnose and treat these issues, since many older adults experience problems with small blood vessels that aren’t addressed by current treatments.

To participate in the trial, individuals must be over 60 years old, not have been diagnosed with type 2 diabetes, and be able to speak and understand Danish for testing purposes. Participants will undergo imaging tests to assess their brain and heart health and may engage in physical activities to see if it helps improve their cognitive function. It’s important to note that those with certain medical conditions, like significant heart or brain issues, or who are already exercising intensely, won’t be eligible. This trial aims to shed light on the connections between heart health, brain function, and diabetes in older adults.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age \> 60 years
• • No diagnosis of T2D according to WHO\'s criteria.
• • Speaks and understands Danish (required for reliable cognitive testing)
• • Able to provide informed and written consent
• Exclusion Criteria:
• • Moderate to high intensity training \>2 times/week.
• • Previous AMI, atrial fibrillation, significant cardiac valve disease, HFrEF (LVEF \<45%), asthma.
• • Previous stroke or significant neurological disease including cognitive dysfunction.
• • Ongoing depression.
• • Hypothyroidism
• • Unable or unwilling to participate in training, e.g., due to injury, arthrosis or lung disease.