The Relationship Between Brain Injury Biomarkers in Cerebrospinal Fluid and Blood of Patients After Cardiac Arrest and Prognosis

Launched by TANG ZIREN · Sep 30, 2024

Keywords

ClinConnect Summary

This clinical trial is looking at how certain markers in the fluid surrounding the brain and in the blood can help predict the recovery of patients who have experienced a cardiac arrest. After a patient has been successfully revived with cardiopulmonary resuscitation (CPR), they will receive special care in the intensive care unit. At different times during their treatment, doctors will perform a procedure called a lumbar puncture to collect samples of cerebrospinal fluid (the fluid around the brain) and blood. These samples will be tested for specific markers that may indicate the extent of brain injury and help determine the patient’s chances of recovery.

To be eligible for this study, participants must be at least 18 years old and still not able to move after being revived from cardiac arrest. They must also receive advanced medical support and temperature management within six hours of being revived. It's important to note that certain patients may not qualify, such as those with specific brain injuries, bleeding issues, or who are pregnant. Throughout the trial, participants will be monitored for three months to see how well they recover, using a scale that assesses their brain function. This study aims to improve our understanding of brain injuries after cardiac arrest and could lead to better treatment strategies in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age ≥ 18 years old.
• • Still lack of directive movements after restoration of spontaneous circulation through cardiopulmonary resuscitation.
• • Advanced life support and targeted temperature management are carried out within 6 hours after return of spontaneous circulation (ROSC).
• Exclusion Criteria:
• • Patients with contraindications for lumbar puncture (severe cerebral edema indicated by brain imaging, disappearance of basal cisterns or occult intracranial mass lesions, receiving antiplatelet and anticoagulant therapy, and those with coagulation disorders).
• • Pregnant patients.
• • Patients with concomitant traumatic brain injury, stroke, cerebral hemorrhage and other diseases.
• • Patients whose families do not agree to be enrolled.