Exploring How Viral Infections Affect People With Chronic Lung Disease

Launched by IMPERIAL COLLEGE LONDON · Oct 1, 2024

Keywords

ClinConnect Summary

This clinical trial is looking at how viral infections might affect people with chronic lung diseases, such as bronchiectasis and COPD (Chronic Obstructive Pulmonary Disease). Researchers want to find out if viruses are a significant cause of flare-ups, which are times when patients feel worse and may need extra treatment. To do this, they will recruit adults who have been diagnosed with these conditions and have had at least one flare-up in the past year. Participants will provide samples like nose swabs and blood tests both when they feel well and during flare-ups. This study will last for up to two years, allowing researchers to observe how these infections and the body’s immune response change over time.

To be eligible for the trial, participants need to be adults with a confirmed diagnosis of a chronic lung disease and a history of flare-ups that required medication. However, those who have had an exacerbation in the last four weeks or are currently pregnant cannot join. Participants can expect to keep a daily diary of their symptoms and attend regular check-ups where they will provide samples for the study. This research aims to improve understanding of how viral infections impact chronic lung conditions and could lead to better treatments in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Adults with a physician confirmed diagnosis of chronic airway disease (e.g. COPD and bronchiectasis) according to established diagnostic criteria.
• • AND
• • - Prior history of exacerbation within last year (defined as requiring antibiotic and/or corticosteroids).
• Exclusion Criteria:
• • Inability to complete daily symptom diaries and/or attend for clinical assessments.
• • Exacerbation within 4 weeks of study recruitment and/or clinical instability at the time of recruitment.
• • Pregnancy.