Nicotinamide Adenine Dinucleotide (NAD+) Metabolism in Human Brown Adipose Tissue

Launched by UNIVERSITY OF TURKU · Oct 2, 2024

Keywords

ClinConnect Summary

This clinical trial is studying how a molecule called Nicotinamide Adenine Dinucleotide (NAD+) affects brown fat in adults. Brown fat is a type of fat that helps us maintain a healthy weight and lowers the risk of diseases like type II diabetes. As we age, our brown fat doesn't work as well, which can lead to unhealthy weight gain, especially around the belly. Researchers want to find out if treatments that boost NAD+ levels can improve how brown fat works and help with overall insulin sensitivity, which is important for managing weight and preventing obesity-related health issues.

To participate in this trial, you need to be between 30 and 55 years old and have a normal weight or be considered obese based on specific measurements. You will also need to be able to read and speak English, Finnish, or Swedish well enough to understand the study instructions. If you have certain health conditions, like diabetes or thyroid issues, or if you recently had surgery or an infection, you may not be eligible. Participants can expect to undergo tests that assess their brown fat function, and the study will help researchers understand how to better support weight management in adults.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Willingness to provide informed consent to participate in the BATNAD study
• • Must be able to read and speak English/Finnish/Swedish well enough to completely understand the instructions and provide informed consent
• • Age 30-55 (sedentary lifestyle)
• • BMI = 18-25 kg/m2 (normal-weight subjects)
• • BMI ≥ 28 kg/m2 and waist circumference more than 100 cm in men and more than 90 cm in women (subjects with obesity)
• Exclusion Criteria:
• • Inability to have PET/CT (claustrophobia, metal implants, recent tattoo including metal components, weight \> 200 kg)
• • Pregnancy and pregnancy related conditions (postpartum/lactation during the last 12 months, or planning to become pregnant soon)
• • Major alterations in the menstrual cycle (e.g., amenorrhea)
• • Use of nicotine based products
• • Hypo- or hyper- thyroidism (medical history, TSH, T3 or T4 levels out of the normal range)
• • Diabetes mellitus (fasting Hb1Ac \>6.5% or fasting glycaemia\> 7.0 mmol/)
• • Abnormal oral glucose tolerance test (2h OGTT \> 11.1 mmol/L)
• • Hypertension (blood pressure \> 160/100 mmHg)
• • Abnormal cardiovascular status (arrhythmia and/or long QTc in ECG, abnormal cardiac murmur, previous history of cardiovascular disease)
• • Abnormal coagulopathy (e.g., clotting abnormality)
• • Malignancies
• • Immunological, autoimmune and primary/secondary immunodeficiency disorders (including or not any active treatment)
• • Virus or bacterial infection (both asymptomatic and symptomatic picture) within the 45 days prior to the study start
• • Vaccination within the 45 days prior to the study start
• • Episode of fever or major surgery, burns and traumas within the month prior to the study start
• • Chronic infections requiring chronic antibiotic or anti-viral treatment
• • Whole blood donation in the last 3 months (\>400 mL of blood) or plans for blood donation during the entire protocol period
• • Weight change (intentional or not) over the last 6-months more than 5% of body weight, or plan to lose weight during the study
• • Allergy to lidocaine or epinephrine, or other local anaesthetics
• • Previous participation to studies where PET or CT method is used
• • Use of any medication that, in the opinion of local clinician/researcher, would negatively impact or mitigate full participation and completion, or could influence the study results. This especially applies to the use of β or α adrenergic receptors agonists/antagonists (e.g., β-blockers).
• • Any other cardiovascular, pulmonary, orthopaedic, neurologic, psychiatric or other conditions that, in the opinion of the local clinician/researcher, would preclude participation and successful completion of the protocol, or that would negatively impact or mitigate participation in and completion of the protocol