Study of Low-intensity Focused Ultrasound Effects on Human Memory

Launched by VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY · Oct 2, 2024

Keywords

ClinConnect Summary

This study employs a two-arm, sham-controlled, repeated measures design conducted across eight sessions:

Overall Structure

* Session 1: Baseline Assessment and Imaging
* Session 2-8: LIFU Stimulation \*The order of Sessions 2-8 is ideally randomized to control for order effects. The study design allows for flexibility to accommodate varying levels of participant completion while maintaining scientific validity.

Detailed Session Breakdown Session 1: Baseline Assessment and Imaging

* Structural \& Functional imaging: MRI and CT anatomical scans
* Administration of questionnaire batter...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Subjects of all ethnicities, who understand and speak English.
• Exclusion Criteria:
• • The exclusion criteria below are regularly implemented in MRI, CT, and EEG experiments for the safety of the subjects and for data quality assurance.
• • 1. Claustrophobia (scanning environment may be uncomfortable).
• • 2. Contraindications to MRI: including pacemaker, aneurysm clips, neurostimulators, cochlear implants, metal in eyes, steel worker, or other implants.
• • 3. Contraindications to CT: pregnancy
• • 4. Active medical disorder or treatment with potential CNS effects (e.g. Alzheimer\'s)
• • 5. History of neurologic disorder. (e.g. Parkinson\'s, Epilepsy, or Essential Tremor)
• • 6. History of head injury resulting in loss of consciousness for \>10 minutes.
• • 7. History of alcohol or drug dependence (through self-report).