Effect of Modified Poco-Poco Exercise to Frailty Stages, Expression of Global DNA Methylation, GDF15 and Lamin A COP

Launched by UNIVERSITAS PADJADJARAN · Oct 3, 2024

Keywords

ClinConnect Summary

This clinical trial is studying the effects of a modified exercise program called poco-poco on older adults who are in a pre-frailty stage. The researchers want to understand if this exercise can change certain health markers related to aging, such as DNA methylation (which is a way our genes can be turned on or off), levels of a protein called GDF15, and another marker known as Lamin A COP. They also want to see if participating in the exercise program can help reduce frailty and improve the overall health of elderly individuals living in Bandung.

To join the study, participants must be older adults living in Bandung who are showing early signs of frailty but are still able to engage in some physical activity. They should have a cognitive score above 18, indicating they can understand instructions. Participants will take part in the modified poco-poco exercise, which includes activities to improve flexibility, balance, aerobic fitness, and strength, three times a week for 12 weeks. It's important to note that individuals with certain health issues, such as severe joint problems or cognitive impairments, will not be eligible for this trial. This study aims to help understand how physical activity can support healthier aging in older adults.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Frailty level is in pre-frailty
• • 2. MoCA INA score above 18
• • 3. Domicile in Bandung City
• • 4. Willing to participate in the study after informed consent
• Exclusion Criteria:
• • 1. There is a hearing impairment that may prevent the subject from receiving verbal instructions
• • 2. There is uncorrected visual impairment
• • 3. There are musculoskeletal disorders so that they cannot perform exercise procedures or procedures for measuring research variables
• • 4. Subjects received other rehabilitation programs
• • 5. Post-stroke with average limb muscle strength below three
• • 6. There are diseases that cause impaired cognition such as Alzheimer\'s disease, traumatic head injury, Parkinson\'s disease.
• • 7. There are severe joint diseases such as osteoarthritis and rheumatoid arthritis that may worsen during exercise or may cause difficulty in carrying out the exercise program.
• • 8. Severe cardiovascular disease as assessed by a heart and vascular specialist
• • 9. Unable to attend Exercises regularly