Cognitive Control Training for Extinction in PTSD

Launched by VA OFFICE OF RESEARCH AND DEVELOPMENT · Oct 4, 2024

Keywords

ClinConnect Summary

This clinical trial is studying a new approach to help veterans with post-traumatic stress disorder (PTSD) by using a program called working memory training (WMT). This program aims to improve the ability to remember and focus on important tasks, which may help reduce fear and anxiety related to past traumatic events. Researchers believe that if WMT can enhance the way veterans learn to cope with fear, it could be a useful addition to existing treatments, like exposure therapy, or even work as a standalone therapy.

To participate in this study, individuals need to meet certain criteria. They must be fluent in English, have a diagnosis of PTSD, and be willing to join eight remote training sessions over four weeks, along with undergoing MRI scans before and after the training. Participants should have stable treatment for at least four weeks prior to joining the trial. However, some individuals, such as those with a history of severe mental health issues or certain neurological conditions, may not be eligible. If you or someone you know is interested, this trial could be an opportunity to explore a new way to manage PTSD symptoms.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Fluent in English
• • Meet current DSM-5 criteria for Posttraumatic Stress Disorder
• • Are willing to attend 8 total remote sessions of working memory training over course of four weeks
• • Are willing to attend MRI scans pre and post working memory training
• • 4-week stability on pharmacological and psychosocial treatments
• Exclusion Criteria:
• • A lifetime history of psychotic disorders, lifetime history of bipolar disorder
• • Past-year severe substance use and severe alcohol use disorder. Mild-to-moderate alcohol use disorder will be allowed to enhance generalizability in our sample due to the high comorbidity of alcohol use and PTSD
• • History of any neurological disorder that might be associated with cognitive dysfunction (e.g., cerebrovascular accident, intracranial surgery, aneurysm, seizure disorder)
• • Acute suicidality requiring immediate clinical intervention
• • Moderate to severe traumatic brain injury (TBI). However, mild to moderate levels of TBI (mTBI) will be included.
• • Receiving benzodiazepines or medications with anticholinergic effects that may affect fear learning measures
• • Inability to safely complete fMRI session (i.e., metal in body, medical implants)