Brain Blood Vessel Responses to Changes in Blood Flow

Launched by UNIVERSITY OF WISCONSIN, MADISON · Oct 4, 2024

Keywords

ClinConnect Summary

This clinical trial, titled "Brain Blood Vessel Responses to Changes in Blood Flow," is investigating how blood flow in the brain responds to changes in position and when breathing in higher levels of carbon dioxide. Researchers will use a type of imaging called magnetic resonance imaging (MRI) to measure these changes. The study aims to better understand cerebrovascular circulation, which is how blood moves through the brain's blood vessels.

To participate in this trial, individuals need to be between the ages of 55 and 69, have a body mass index (BMI) of 34.5 or lower, and must be nonsmokers. Additionally, women must be postmenopausal. However, people with certain health conditions like mild cognitive impairment, Alzheimer's disease, or serious heart and kidney issues cannot take part. If eligible, participants can expect to undergo tests while lying in an MRI machine, which is a painless procedure, to help gather information on how their brain responds to different conditions. It's important to note that the trial is not yet recruiting participants, so there may be a wait before it starts.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Between the ages of 55-69 years
• • Have a BMI ≤34.5 kg/m2
• • Nonsmoker
• • Females must be postmenopausal
• Exclusion Criteria:
• • Diagnosis of Mild Cognitive Impairment (MCI) or Alzheimer's disease (AD)
• • History or evidence of hepatic disease, hematological disease, or peripheral vascular disease; severe kidney injury requiring hemodialysis
• • History of cardiovascular disease including: severe congestive heart failure, coronary artery disease, ischemic heart disease (stents, coronary artery bypass grafts) and tachycardia
• • Uncontrolled hypertension
• • History of clinically significant ischemic or hemorrhagic stroke, or significant cerebrovascular disease
• • Severe untreated obstructive sleep apnea
• • History of diabetes with HbA1c greater than 9.5%
• • Major neurologic disorders other than dementia (e.g., MS, ALS, brain surgery, etc.)
• • Current or recent (\<1 year) major psychiatric condition (Axis I) or addictive disorders
• • Significant surgical history
• • Other significant medical conditions at investigators' discretion
• • Contraindications to MRI
• • Prescribed medications that interfere with prazosin
• • Lactose allergy