Use of Shear Wave Elastography for Intraoperative Brain and Glioma Stiffness Measurements

Launched by MAYO CLINIC · Oct 4, 2024

Keywords

ClinConnect Summary

This clinical trial is studying a new technique called intraoperative shear wave elastography ultrasound (ISWEU) to help doctors measure the stiffness of brain tissue during surgery for gliomas, which are a type of brain tumor. By understanding the differences in stiffness between healthy brain tissue and the tumor, surgeons hope to improve the way they remove gliomas in future patients. The trial is not yet recruiting participants, but it will include adults aged 18 and older who need surgery for either a newly diagnosed or recurrent glioma.

To be eligible for the study, participants must have a planned surgery where the tumor is located in an area of the brain that is easy to reach safely with the ultrasound probe. They also need to be in good overall health, as measured by a specific performance scale. Participants will need to provide written consent to take part in the study. It's important to note that individuals with certain conditions, such as deep-seated brain tumors or infections, will not be eligible to participate. Overall, this trial aims to enhance surgical techniques and outcomes for patients undergoing treatment for gliomas.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients must be at least 18 years old.
• • Patients must have planned surgery for resection of a newly diagnosed or recurrent glioma.
• • Patients with tumors located in the brain cortex or superficial white matter in which introduction of the ultrasound probe is straightforward and does not pose a risk for intraoperative complications.
• • Patients must have a Karnofsky performance status ≥ 60%.
• • Patient or legally authorized representative (LAR) willing to provide written informed consent.
• Exclusion Criteria:
• • Patients with deep-seated brain tumors in which introduction of the ultrasound probe poses an increased risk.
• • Patients with a history of any brain infections.
• • Patients with implanted devices.
• • Patients with any other neurological/neurosurgical disease that could affect tissue stiffness.
• • Patients with any other structural brain defect that could affect tissue stiffness.