PREVENTION OF WORSENING RENAL FUNCTION OF INTRAVENUS ALBUMIN IN HEART FAILURE PATIENTS

Launched by DEMOCRITUS UNIVERSITY OF THRACE · Oct 4, 2024

Keywords

ClinConnect Summary

This clinical trial is looking at a way to help heart failure patients who are experiencing worsening kidney function while being treated in the hospital. When heart failure gets worse, it can lead to problems with kidney function, making it harder for doctors to remove excess fluid from the body. The researchers believe that patients with liver problems might be at higher risk for kidney issues when treated with regular diuretics (medications that help remove fluid). They are testing whether using intravenous (IV) human albumin, along with diuretics, can help these patients recover better and prevent further kidney damage.

To be eligible for the study, participants must be over 18 years old, have acute heart failure, and show signs of liver dysfunction. They also need to have been treated with oral diuretics before and require IV diuretics for at least three days. If someone joins the study, they can expect to receive either the new treatment or standard care while being closely monitored for their heart and kidney functions. This trial is currently recruiting participants, and it’s important for patients to discuss with their healthcare providers if this study might be a good option for them.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. age over 18 yrs
• • 2. acute decompensation of CHF
• • 3. evidence of hepatic dysfunction by laboratory biochemical measurements or imaging (liver ultrasonography)
• • 4. history of CHF with previous use of an oral loop diuretic
• • 5. anticipated need for IV diuretic therapy for at least 72 hours
• • There is no pre-specified inclusion criterion with respect to ejection fraction
• Exclusion Criteria:
• • 1. hemodynamic collapse (at least one of the following: systolic blood pressure (BP) \< 90 mmHg, or BP drop by \>= 40 mmHg for \>= 15 min, with end-organ hypoperfusion; need for inotropes (except of digoxin); need for cardiopulmonary resuscitation).
• • 2. hepatic dysfunction of other than cardiac etiology
• • 3. severe anemia (Hb\<8 g/dL)
• • 4. uncontrolled hypertension or hypertensive emergency/urgency
• • 5. pulmonary edema or pulmonary congestion necessitating use of IV vasodilators
• • 6. serum creatinine \> 3 mg/dL or glomerular filtration rate (GFR) \< 30 ml/min