D3-Creatine and Skeletal Muscle in Older Adults

Launched by MCMASTER UNIVERSITY · Oct 6, 2024

Keywords

ClinConnect Summary

The D3-Creatine and Skeletal Muscle trial is studying how a new method can better measure muscle mass in older adults who may be experiencing muscle loss due to aging, a condition known as sarcopenia. This trial will involve about 350 participants aged between 60 and 80 years who live within 60 kilometers of Hamilton. To be eligible, participants should have some self-reported mobility limitations, such as difficulty walking 800 meters, climbing ten steps, or getting in and out of a car or bus, but they should not have significant difficulties with these tasks.

Participants in the study can expect to undergo various measurements at the start of the trial and again after one and two years. These measurements will include assessing muscle mass using a new, non-invasive tool called D3-Creatine, along with traditional methods. The trial aims to find more accurate ways to evaluate muscle health, which is important for understanding and addressing mobility issues in older adults. If you're interested in participating, you'll need to be able to read and understand English and be willing to provide written consent.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Participants will be considered eligible for this study if they are
• • Between 60 and 80y (inclusive),
• • Reside in the local (i.e., within 60km of Hamilton) community; and
• • Are willing and able to provide written informed consent.
• Participants must fall into one of three self-reported mobility limitations based on validated screening criteria via a structured phone interview. Potential participants will be asked whether they have any difficulty:
• • Walking 800m;
• • Climbing ten steps; and
• • Transferring from/into a car or bus.
• Response options include:
• • Managing without difficulty;
• • Managing without difficulty but with task modification; or
• • Managing with minor difficulty.
• Exclusion Criteria:
• • Participants who self-report more than minor difficulty will be considered to have a mobility disability and excluded.
• • Participants who cannot speak or read English will also be excluded.