Comparing Impact of Treatment Before or After Surgery in Patients With Stage II-IIIB Resectable Non-small Cell Lung Cancer
Launched by ALLIANCE FOR CLINICAL TRIALS IN ONCOLOGY · Oct 7, 2024
Trial Information
Current as of July 09, 2025
Recruiting
Keywords
ClinConnect Summary
This clinical trial is exploring the best way to treat patients with stage II to IIIB non-small cell lung cancer (NSCLC) that can be surgically removed. The study compares two treatment methods: one where patients receive standard therapy only after surgery, and another where they receive therapy both before and after surgery. The goal is to see which approach works better for fighting the cancer and improving outcomes for patients. Treatments may include chemotherapy and immunotherapy, which are designed to kill cancer cells or help the body’s immune system fight the cancer.
To participate in this trial, patients must be at least 18 years old and have a specific type of lung cancer that is resectable, meaning it can be surgically removed. They should not have had any previous treatment for lung cancer in the past five years, and there are some health criteria to ensure safety during the treatment. Participants can expect to receive care that aligns with the current standard practices, and they will be closely monitored throughout the trial. This study is currently recruiting participants, and it aims to provide valuable insights into the most effective treatment strategies for lung cancer.
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Histologically or cytologically confirmed surgically resectable stage IIA to IIIB NSCLC according to the American Joint Committee on Cancer (AJCC) 9th edition (stage IIA to IIIB NSCLC up to single station N2, according to the AJCC 8th edition)
- • \* Note: Patients with resectable stage N2a or T4 are eligible, but patients with stage N2b or N3 are not eligible. Patients with known EGFR or ALK alterations are excluded
- • Age ≥ 18 years
- • Eastern Cooperative Oncology Group (ECOG) performance status ≤ 2 (or Karnofsky ≥ 60%)
- • No prior systemic treatment for NSCLC within 5 years except stage 1 and 2 cancers treated with curative intent
- • No treatment for another malignancy within 3 years prior to registration, except for stage 1 or 2 cancers treated for curative intent; patients must be disease free for one year prior to registration. Patients with non-melanoma skin cancer, urothelial carcinoma in situ (Tis), noninvasive papillary carcinoma of the urinary bladder (Ta), prostatic intraepithelial neoplasia (PIN), ductal carcinoma in situ (DCIS) of the breast, or cervical intraepithelial neoplasia (CIN) of the uterine cervix are also eligible
- • No active autoimmune disease, interstitial lung disease, or transplant that precludes safe treatment with immune checkpoint inhibitors
- • HIV-infected patients on effective anti-retroviral therapy with undetectable viral load within 6 months are eligible for this trial
About Alliance For Clinical Trials In Oncology
The Alliance for Clinical Trials in Oncology is a prominent cooperative group dedicated to conducting high-quality, innovative clinical research aimed at improving cancer treatment and patient outcomes. Comprising a diverse network of institutions and investigators, the Alliance focuses on developing and implementing clinical trials that evaluate new therapies, treatment combinations, and prevention strategies across various cancer types. By fostering collaboration among oncologists, researchers, and healthcare professionals, the Alliance aims to accelerate the translation of scientific discoveries into effective clinical practices, ultimately enhancing the standard of care for cancer patients.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Chicago, Illinois, United States
Milwaukee, Wisconsin, United States
Charleston, South Carolina, United States
Saint Louis, Missouri, United States
Edina, Minnesota, United States
Waconia, Minnesota, United States
Peoria, Illinois, United States
Bangor, Maine, United States
Oklahoma City, Oklahoma, United States
La Crosse, Wisconsin, United States
Great Falls, Montana, United States
Saint Paul, Minnesota, United States
Cincinnati, Ohio, United States
Charlottesville, Virginia, United States
Lewes, Delaware, United States
Salina, Kansas, United States
Gresham, Oregon, United States
Tualatin, Oregon, United States
Coon Rapids, Minnesota, United States
Urbana, Illinois, United States
Minneapolis, Minnesota, United States
Saint Paul, Minnesota, United States
Shakopee, Minnesota, United States
Willmar, Minnesota, United States
Effingham, Illinois, United States
Lawrence, Kansas, United States
Saint Joseph, Missouri, United States
Greenville, Ohio, United States
Wisconsin Rapids, Wisconsin, United States
Longmont, Colorado, United States
Springfield, Illinois, United States
Cincinnati, Ohio, United States
Englewood, New Jersey, United States
Minneapolis, Minnesota, United States
Rochester, New York, United States
Birmingham, Alabama, United States
Sacramento, California, United States
Washington, District Of Columbia, United States
Boston, Massachusetts, United States
Saint Louis, Missouri, United States
Kearney, Nebraska, United States
Syracuse, New York, United States
Syracuse, New York, United States
Bismarck, North Dakota, United States
Fargo, North Dakota, United States
Newark, Delaware, United States
Aurora, Illinois, United States
Kettering, Ohio, United States
Cape Girardeau, Missouri, United States
Washington, District Of Columbia, United States
Pueblo, Colorado, United States
Robbinsdale, Minnesota, United States
Saint Louis Park, Minnesota, United States
Saint Louis, Missouri, United States
Omaha, Nebraska, United States
Memphis, Tennessee, United States
Omaha, Nebraska, United States
Glens Falls, New York, United States
Oakland, California, United States
Sioux Falls, South Dakota, United States
Rochester, Minnesota, United States
Saint Louis, Missouri, United States
Green Bay, Wisconsin, United States
Marshfield, Wisconsin, United States
Decatur, Illinois, United States
Ottawa, Illinois, United States
Peoria, Illinois, United States
Cedar Rapids, Iowa, United States
Cedar Rapids, Iowa, United States
Omaha, Nebraska, United States
Peru, Illinois, United States
Maplewood, Minnesota, United States
Maplewood, Minnesota, United States
Stillwater, Minnesota, United States
Findlay, Ohio, United States
Rohnert Park, California, United States
Sacramento, California, United States
Fremont, California, United States
Richmond, California, United States
Roseville, California, United States
Sacramento, California, United States
San Francisco, California, United States
San Jose, California, United States
San Leandro, California, United States
Santa Clara, California, United States
Santa Rosa, California, United States
South San Francisco, California, United States
Stockton, California, United States
Vallejo, California, United States
Walnut Creek, California, United States
Galesburg, Illinois, United States
Richmond, Indiana, United States
Topeka, Kansas, United States
New Orleans, Louisiana, United States
Baltimore, Maryland, United States
Elkton, Maryland, United States
Bemidji, Minnesota, United States
Woodbury, Minnesota, United States
Joplin, Missouri, United States
Springfield, Missouri, United States
Springfield, Missouri, United States
Billings, Montana, United States
Boardman, Ohio, United States
Warren, Ohio, United States
Youngstown, Ohio, United States
Portland, Oregon, United States
Sioux Falls, South Dakota, United States
Green Bay, Wisconsin, United States
Oconomowoc, Wisconsin, United States
Oconto Falls, Wisconsin, United States
Rice Lake, Wisconsin, United States
Waukesha, Wisconsin, United States
Wausau, Wisconsin, United States
Weston, Wisconsin, United States
Kettering, Ohio, United States
Colorado Springs, Colorado, United States
Lakewood, Colorado, United States
Chicago, Illinois, United States
Burlington, Massachusetts, United States
Antigo, Wisconsin, United States
Wausau, Wisconsin, United States
Florence, South Carolina, United States
New Ulm, Minnesota, United States
Albuquerque, New Mexico, United States
Honolulu, Hawaii, United States
Chippewa Falls, Wisconsin, United States
Canton, Illinois, United States
Carthage, Illinois, United States
Eureka, Illinois, United States
Kewanee, Illinois, United States
Macomb, Illinois, United States
Peru, Illinois, United States
Princeton, Illinois, United States
Boise, Idaho, United States
Hines, Illinois, United States
Appleton, Wisconsin, United States
La Jolla, California, United States
Warrenville, Illinois, United States
Joplin, Missouri, United States
Houston, Texas, United States
Ft. Smith, Arkansas, United States
Grand Island, Nebraska, United States
Fort Smith, Arkansas, United States
Post Falls, Idaho, United States
Bloomington, Illinois, United States
Geneva, Illinois, United States
Pekin, Illinois, United States
Bolivar, Missouri, United States
Branson, Missouri, United States
Saint Louis, Missouri, United States
Lawton, Oklahoma, United States
Greenwood, South Carolina, United States
Wisconsin Rapids, Wisconsin, United States
Carmichael, California, United States
Vacaville, California, United States
Goshen, Indiana, United States
Ashland, Kentucky, United States
Owensboro, Kentucky, United States
Baltimore, Maryland, United States
Saint Louis, Missouri, United States
Omaha, Nebraska, United States
Oklahoma City, Oklahoma, United States
Antioch, California, United States
Fresno, California, United States
Modesto, California, United States
Oakland, California, United States
Rancho Cordova, California, United States
Roseville, California, United States
South San Francisco, California, United States
Rolla, Missouri, United States
Fargo, North Dakota, United States
Vancouver, Washington, United States
New Richmond, Wisconsin, United States
Springfield, Illinois, United States
Saint Peters, Missouri, United States
Great Falls, Montana, United States
Newark, Delaware, United States
Newark, Delaware, United States
Rehoboth Beach, Delaware, United States
Wilmington, Delaware, United States
Caldwell, Idaho, United States
Coeur D'alene, Idaho, United States
Meridian, Idaho, United States
Garden City, Kansas, United States
Great Bend, Kansas, United States
Minneapolis, Minnesota, United States
Anaconda, Montana, United States
Westwood, New Jersey, United States
Cody, Wyoming, United States
Colorado Springs, Colorado, United States
Durango, Colorado, United States
Durango, Colorado, United States
Bardstown, Kentucky, United States
Corbin, Kentucky, United States
Lexington, Kentucky, United States
Lexington, Kentucky, United States
Cincinnati, Ohio, United States
Cincinnati, Ohio, United States
Carbondale, Illinois, United States
Carterville, Illinois, United States
Centralia, Illinois, United States
Decatur, Illinois, United States
Effingham, Illinois, United States
Mattoon, Illinois, United States
O'fallon, Illinois, United States
Yorkville, Illinois, United States
Maple Grove, Minnesota, United States
Wyoming, Minnesota, United States
Sainte Genevieve, Missouri, United States
Sullivan, Missouri, United States
Centerville, Ohio, United States
Cincinnati, Ohio, United States
Findlay, Ohio, United States
Findlay, Ohio, United States
Franklin, Ohio, United States
Greenville, Ohio, United States
Sturgeon Bay, Wisconsin, United States
Dublin, California, United States
Fresno, California, United States
Sacramento, California, United States
San Rafael, California, United States
Monticello, Minnesota, United States
Columbus, Mississippi, United States
Grenada, Mississippi, United States
New Albany, Mississippi, United States
Oxford, Mississippi, United States
Southhaven, Mississippi, United States
Creve Coeur, Missouri, United States
Saint Louis, Missouri, United States
Ridgewood, New Jersey, United States
Eau Claire, Wisconsin, United States
Milwaukee, Wisconsin, United States
Bronx, New York, United States
London, Kentucky, United States
Mukwonago, Wisconsin, United States
Waukesha, Wisconsin, United States
Phoenix, Arizona, United States
Phoenix, Arizona, United States
Elk Grove, California, United States
Rocklin, California, United States
Sacramento, California, United States
San Luis Obispo, California, United States
Santa Maria, California, United States
Woodland, California, United States
Brewer, Maine, United States
Las Cruces, New Mexico, United States
Dekalb, Illinois, United States
Beavercreek, Ohio, United States
Stevens Point, Wisconsin, United States
Arroyo Grande, California, United States
Saint Louis, Missouri, United States
Collierville, Tennessee, United States
Medford, Wisconsin, United States
Stockton, California, United States
Ballwin, Missouri, United States
Washington, Missouri, United States
Worthington, Minnesota, United States
Lake Forest, Illinois, United States
Fargo, North Dakota, United States
Chadds Ford, Pennsylvania, United States
Dixon, Illinois, United States
Washington, Illinois, United States
Farmington, Missouri, United States
Redwood City, California, United States
Colorado Springs, Colorado, United States
Peabody, Massachusetts, United States
Burnsville, Minnesota, United States
Bozeman, Montana, United States
Cambridge, Minnesota, United States
Princeton, Minnesota, United States
Thief River Falls, Minnesota, United States
Oswego, New York, United States
Paramus, New Jersey, United States
Newnan, Georgia, United States
Neenah, Wisconsin, United States
New London, Wisconsin, United States
Shawano, Wisconsin, United States
Waupaca, Wisconsin, United States
Vancouver, Washington, United States
Missoula, Montana, United States
Oshkosh, Wisconsin, United States
Little Rock, Arkansas, United States
Fargo, North Dakota, United States
Fargo, North Dakota, United States
Alton, Illinois, United States
Springfield, Illinois, United States
Lexington, Kentucky, United States
Shiloh, Illinois, United States
Sheboygan, Wisconsin, United States
Berlin, Wisconsin, United States
Kansas City, Missouri, United States
Kalispell, Montana, United States
Mount Sterling, Kentucky, United States
Troy, Ohio, United States
Nampa, Idaho, United States
Centralia, Illinois, United States
Webster, New York, United States
Neillsville, Wisconsin, United States
Danville, Illinois, United States
Orland Park, Illinois, United States
Merced, California, United States
Rhinelander, Wisconsin, United States
Stevens Point, Wisconsin, United States
Ladysmith, Wisconsin, United States
Minocqua, Wisconsin, United States
Osage Beach, Missouri, United States
Verona, New York, United States
Glenview, Illinois, United States
Grayslake, Illinois, United States
Sunset Hills, Missouri, United States
O'fallon, Illinois, United States
Carmichael, California, United States
Rockford, Illinois, United States
Hays, Kansas, United States
Escanaba, Michigan, United States
Ridgewood, New Jersey, United States
Silverdale, Washington, United States
Dayton, Ohio, United States
Sandpoint, Idaho, United States
Baker City, Oregon, United States
Ontario, Oregon, United States
Millville, Delaware, United States
Havre, Montana, United States
Olathe, Kansas, United States
Westminster, Colorado, United States
Mount Vernon, Illinois, United States
Sheboygan, Wisconsin, United States
Rolla, Missouri, United States
Cape Girardeau, Missouri, United States
Patients applied
Trial Officials
Daniel Morgensztern, MD
Study Chair
Alliance for Clinical Trials in Oncology
Raid Aljumaily, MD
Study Chair
Alliance for Clinical Trials in Oncology
Linda Martin, MD
Study Chair
Alliance for Clinical Trials in Oncology
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported