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Search / Trial NCT06632327

Comparing Impact of Treatment Before or After Surgery in Patients With Stage II-IIIB Resectable Non-small Cell Lung Cancer

Launched by ALLIANCE FOR CLINICAL TRIALS IN ONCOLOGY · Oct 7, 2024

Trial Information

Current as of July 09, 2025

Recruiting

Keywords

ClinConnect Summary

This clinical trial is exploring the best way to treat patients with stage II to IIIB non-small cell lung cancer (NSCLC) that can be surgically removed. The study compares two treatment methods: one where patients receive standard therapy only after surgery, and another where they receive therapy both before and after surgery. The goal is to see which approach works better for fighting the cancer and improving outcomes for patients. Treatments may include chemotherapy and immunotherapy, which are designed to kill cancer cells or help the body’s immune system fight the cancer.

To participate in this trial, patients must be at least 18 years old and have a specific type of lung cancer that is resectable, meaning it can be surgically removed. They should not have had any previous treatment for lung cancer in the past five years, and there are some health criteria to ensure safety during the treatment. Participants can expect to receive care that aligns with the current standard practices, and they will be closely monitored throughout the trial. This study is currently recruiting participants, and it aims to provide valuable insights into the most effective treatment strategies for lung cancer.

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • Histologically or cytologically confirmed surgically resectable stage IIA to IIIB NSCLC according to the American Joint Committee on Cancer (AJCC) 9th edition (stage IIA to IIIB NSCLC up to single station N2, according to the AJCC 8th edition)
  • \* Note: Patients with resectable stage N2a or T4 are eligible, but patients with stage N2b or N3 are not eligible. Patients with known EGFR or ALK alterations are excluded
  • Age ≥ 18 years
  • Eastern Cooperative Oncology Group (ECOG) performance status ≤ 2 (or Karnofsky ≥ 60%)
  • No prior systemic treatment for NSCLC within 5 years except stage 1 and 2 cancers treated with curative intent
  • No treatment for another malignancy within 3 years prior to registration, except for stage 1 or 2 cancers treated for curative intent; patients must be disease free for one year prior to registration. Patients with non-melanoma skin cancer, urothelial carcinoma in situ (Tis), noninvasive papillary carcinoma of the urinary bladder (Ta), prostatic intraepithelial neoplasia (PIN), ductal carcinoma in situ (DCIS) of the breast, or cervical intraepithelial neoplasia (CIN) of the uterine cervix are also eligible
  • No active autoimmune disease, interstitial lung disease, or transplant that precludes safe treatment with immune checkpoint inhibitors
  • HIV-infected patients on effective anti-retroviral therapy with undetectable viral load within 6 months are eligible for this trial

About Alliance For Clinical Trials In Oncology

The Alliance for Clinical Trials in Oncology is a prominent cooperative group dedicated to conducting high-quality, innovative clinical research aimed at improving cancer treatment and patient outcomes. Comprising a diverse network of institutions and investigators, the Alliance focuses on developing and implementing clinical trials that evaluate new therapies, treatment combinations, and prevention strategies across various cancer types. By fostering collaboration among oncologists, researchers, and healthcare professionals, the Alliance aims to accelerate the translation of scientific discoveries into effective clinical practices, ultimately enhancing the standard of care for cancer patients.

Locations

Chicago, Illinois, United States

Milwaukee, Wisconsin, United States

Charleston, South Carolina, United States

Saint Louis, Missouri, United States

Edina, Minnesota, United States

Waconia, Minnesota, United States

Peoria, Illinois, United States

Bangor, Maine, United States

Oklahoma City, Oklahoma, United States

La Crosse, Wisconsin, United States

Great Falls, Montana, United States

Saint Paul, Minnesota, United States

Cincinnati, Ohio, United States

Charlottesville, Virginia, United States

Lewes, Delaware, United States

Salina, Kansas, United States

Gresham, Oregon, United States

Tualatin, Oregon, United States

Coon Rapids, Minnesota, United States

Urbana, Illinois, United States

Minneapolis, Minnesota, United States

Saint Paul, Minnesota, United States

Shakopee, Minnesota, United States

Willmar, Minnesota, United States

Effingham, Illinois, United States

Lawrence, Kansas, United States

Saint Joseph, Missouri, United States

Greenville, Ohio, United States

Wisconsin Rapids, Wisconsin, United States

Longmont, Colorado, United States

Springfield, Illinois, United States

Cincinnati, Ohio, United States

Englewood, New Jersey, United States

Minneapolis, Minnesota, United States

Rochester, New York, United States

Birmingham, Alabama, United States

Sacramento, California, United States

Washington, District Of Columbia, United States

Boston, Massachusetts, United States

Saint Louis, Missouri, United States

Kearney, Nebraska, United States

Syracuse, New York, United States

Syracuse, New York, United States

Bismarck, North Dakota, United States

Fargo, North Dakota, United States

Newark, Delaware, United States

Aurora, Illinois, United States

Kettering, Ohio, United States

Cape Girardeau, Missouri, United States

Washington, District Of Columbia, United States

Pueblo, Colorado, United States

Robbinsdale, Minnesota, United States

Saint Louis Park, Minnesota, United States

Saint Louis, Missouri, United States

Omaha, Nebraska, United States

Memphis, Tennessee, United States

Omaha, Nebraska, United States

Glens Falls, New York, United States

Oakland, California, United States

Sioux Falls, South Dakota, United States

Rochester, Minnesota, United States

Saint Louis, Missouri, United States

Green Bay, Wisconsin, United States

Marshfield, Wisconsin, United States

Decatur, Illinois, United States

Ottawa, Illinois, United States

Peoria, Illinois, United States

Cedar Rapids, Iowa, United States

Cedar Rapids, Iowa, United States

Omaha, Nebraska, United States

Peru, Illinois, United States

Maplewood, Minnesota, United States

Maplewood, Minnesota, United States

Stillwater, Minnesota, United States

Findlay, Ohio, United States

Rohnert Park, California, United States

Sacramento, California, United States

Fremont, California, United States

Richmond, California, United States

Roseville, California, United States

Sacramento, California, United States

San Francisco, California, United States

San Jose, California, United States

San Leandro, California, United States

Santa Clara, California, United States

Santa Rosa, California, United States

South San Francisco, California, United States

Stockton, California, United States

Vallejo, California, United States

Walnut Creek, California, United States

Galesburg, Illinois, United States

Richmond, Indiana, United States

Topeka, Kansas, United States

New Orleans, Louisiana, United States

Baltimore, Maryland, United States

Elkton, Maryland, United States

Bemidji, Minnesota, United States

Woodbury, Minnesota, United States

Joplin, Missouri, United States

Springfield, Missouri, United States

Springfield, Missouri, United States

Billings, Montana, United States

Boardman, Ohio, United States

Warren, Ohio, United States

Youngstown, Ohio, United States

Portland, Oregon, United States

Sioux Falls, South Dakota, United States

Green Bay, Wisconsin, United States

Oconomowoc, Wisconsin, United States

Oconto Falls, Wisconsin, United States

Rice Lake, Wisconsin, United States

Waukesha, Wisconsin, United States

Wausau, Wisconsin, United States

Weston, Wisconsin, United States

Kettering, Ohio, United States

Colorado Springs, Colorado, United States

Lakewood, Colorado, United States

Chicago, Illinois, United States

Burlington, Massachusetts, United States

Antigo, Wisconsin, United States

Wausau, Wisconsin, United States

Florence, South Carolina, United States

New Ulm, Minnesota, United States

Albuquerque, New Mexico, United States

Honolulu, Hawaii, United States

Chippewa Falls, Wisconsin, United States

Canton, Illinois, United States

Carthage, Illinois, United States

Eureka, Illinois, United States

Kewanee, Illinois, United States

Macomb, Illinois, United States

Peru, Illinois, United States

Princeton, Illinois, United States

Boise, Idaho, United States

Hines, Illinois, United States

Appleton, Wisconsin, United States

La Jolla, California, United States

Warrenville, Illinois, United States

Joplin, Missouri, United States

Houston, Texas, United States

Ft. Smith, Arkansas, United States

Grand Island, Nebraska, United States

Fort Smith, Arkansas, United States

Post Falls, Idaho, United States

Bloomington, Illinois, United States

Geneva, Illinois, United States

Pekin, Illinois, United States

Bolivar, Missouri, United States

Branson, Missouri, United States

Saint Louis, Missouri, United States

Lawton, Oklahoma, United States

Greenwood, South Carolina, United States

Wisconsin Rapids, Wisconsin, United States

Carmichael, California, United States

Vacaville, California, United States

Goshen, Indiana, United States

Ashland, Kentucky, United States

Owensboro, Kentucky, United States

Baltimore, Maryland, United States

Saint Louis, Missouri, United States

Omaha, Nebraska, United States

Oklahoma City, Oklahoma, United States

Antioch, California, United States

Fresno, California, United States

Modesto, California, United States

Oakland, California, United States

Rancho Cordova, California, United States

Roseville, California, United States

South San Francisco, California, United States

Rolla, Missouri, United States

Fargo, North Dakota, United States

Vancouver, Washington, United States

New Richmond, Wisconsin, United States

Springfield, Illinois, United States

Saint Peters, Missouri, United States

Great Falls, Montana, United States

Newark, Delaware, United States

Newark, Delaware, United States

Rehoboth Beach, Delaware, United States

Wilmington, Delaware, United States

Caldwell, Idaho, United States

Coeur D'alene, Idaho, United States

Meridian, Idaho, United States

Garden City, Kansas, United States

Great Bend, Kansas, United States

Minneapolis, Minnesota, United States

Anaconda, Montana, United States

Westwood, New Jersey, United States

Cody, Wyoming, United States

Colorado Springs, Colorado, United States

Durango, Colorado, United States

Durango, Colorado, United States

Bardstown, Kentucky, United States

Corbin, Kentucky, United States

Lexington, Kentucky, United States

Lexington, Kentucky, United States

Cincinnati, Ohio, United States

Cincinnati, Ohio, United States

Carbondale, Illinois, United States

Carterville, Illinois, United States

Centralia, Illinois, United States

Decatur, Illinois, United States

Effingham, Illinois, United States

Mattoon, Illinois, United States

O'fallon, Illinois, United States

Yorkville, Illinois, United States

Maple Grove, Minnesota, United States

Wyoming, Minnesota, United States

Sainte Genevieve, Missouri, United States

Sullivan, Missouri, United States

Centerville, Ohio, United States

Cincinnati, Ohio, United States

Findlay, Ohio, United States

Findlay, Ohio, United States

Franklin, Ohio, United States

Greenville, Ohio, United States

Sturgeon Bay, Wisconsin, United States

Dublin, California, United States

Fresno, California, United States

Sacramento, California, United States

San Rafael, California, United States

Monticello, Minnesota, United States

Columbus, Mississippi, United States

Grenada, Mississippi, United States

New Albany, Mississippi, United States

Oxford, Mississippi, United States

Southhaven, Mississippi, United States

Creve Coeur, Missouri, United States

Saint Louis, Missouri, United States

Ridgewood, New Jersey, United States

Eau Claire, Wisconsin, United States

Milwaukee, Wisconsin, United States

Bronx, New York, United States

London, Kentucky, United States

Mukwonago, Wisconsin, United States

Waukesha, Wisconsin, United States

Phoenix, Arizona, United States

Phoenix, Arizona, United States

Elk Grove, California, United States

Rocklin, California, United States

Sacramento, California, United States

San Luis Obispo, California, United States

Santa Maria, California, United States

Woodland, California, United States

Brewer, Maine, United States

Las Cruces, New Mexico, United States

Dekalb, Illinois, United States

Beavercreek, Ohio, United States

Stevens Point, Wisconsin, United States

Arroyo Grande, California, United States

Saint Louis, Missouri, United States

Collierville, Tennessee, United States

Medford, Wisconsin, United States

Stockton, California, United States

Ballwin, Missouri, United States

Washington, Missouri, United States

Worthington, Minnesota, United States

Lake Forest, Illinois, United States

Fargo, North Dakota, United States

Chadds Ford, Pennsylvania, United States

Dixon, Illinois, United States

Washington, Illinois, United States

Farmington, Missouri, United States

Redwood City, California, United States

Colorado Springs, Colorado, United States

Peabody, Massachusetts, United States

Burnsville, Minnesota, United States

Bozeman, Montana, United States

Cambridge, Minnesota, United States

Princeton, Minnesota, United States

Thief River Falls, Minnesota, United States

Oswego, New York, United States

Paramus, New Jersey, United States

Newnan, Georgia, United States

Neenah, Wisconsin, United States

New London, Wisconsin, United States

Shawano, Wisconsin, United States

Waupaca, Wisconsin, United States

Vancouver, Washington, United States

Missoula, Montana, United States

Oshkosh, Wisconsin, United States

Little Rock, Arkansas, United States

Fargo, North Dakota, United States

Fargo, North Dakota, United States

Alton, Illinois, United States

Springfield, Illinois, United States

Lexington, Kentucky, United States

Shiloh, Illinois, United States

Sheboygan, Wisconsin, United States

Berlin, Wisconsin, United States

Kansas City, Missouri, United States

Kalispell, Montana, United States

Mount Sterling, Kentucky, United States

Troy, Ohio, United States

Nampa, Idaho, United States

Centralia, Illinois, United States

Webster, New York, United States

Neillsville, Wisconsin, United States

Danville, Illinois, United States

Orland Park, Illinois, United States

Merced, California, United States

Rhinelander, Wisconsin, United States

Stevens Point, Wisconsin, United States

Ladysmith, Wisconsin, United States

Minocqua, Wisconsin, United States

Osage Beach, Missouri, United States

Verona, New York, United States

Glenview, Illinois, United States

Grayslake, Illinois, United States

Sunset Hills, Missouri, United States

O'fallon, Illinois, United States

Carmichael, California, United States

Rockford, Illinois, United States

Hays, Kansas, United States

Escanaba, Michigan, United States

Ridgewood, New Jersey, United States

Silverdale, Washington, United States

Dayton, Ohio, United States

Sandpoint, Idaho, United States

Baker City, Oregon, United States

Ontario, Oregon, United States

Millville, Delaware, United States

Havre, Montana, United States

Olathe, Kansas, United States

Westminster, Colorado, United States

Mount Vernon, Illinois, United States

Sheboygan, Wisconsin, United States

Rolla, Missouri, United States

Cape Girardeau, Missouri, United States

Patients applied

0 patients applied

Trial Officials

Daniel Morgensztern, MD

Study Chair

Alliance for Clinical Trials in Oncology

Raid Aljumaily, MD

Study Chair

Alliance for Clinical Trials in Oncology

Linda Martin, MD

Study Chair

Alliance for Clinical Trials in Oncology

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported