Therapy Evaluation in Patients With Minor Stroke and Large Vessel Occlusion

Launched by SIR RUN RUN SHAW HOSPITAL · Oct 7, 2024

Keywords

ClinConnect Summary

This clinical trial is examining how different treatments work for patients who have experienced a minor stroke caused by a blockage in a large blood vessel. The study specifically looks at patients who have low scores on a scale that measures stroke severity, indicating that their stroke is less severe. By collecting data from multiple centers, the researchers aim to understand the best therapy options and predict outcomes for these patients.

To be eligible for this trial, participants must be at least 18 years old, have experienced an acute ischemic stroke within the last 24 hours, and have specific types of blockages in their brain's blood vessels. They should also have a low severity score and minimal prior disability. Participants can expect to receive regular follow-up care and monitoring during the study. Importantly, individuals with certain health issues, such as bleeding in the brain or major fluctuations in blood sugar, may not qualify for the study. This trial is currently recruiting participants, and both men and women are welcome to join.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Aged 18 years or older
• • 2. Acute ischemic stroke patients of NIHSS 0-5 with 24 hours after onset
• • 3. Proximal intracranial artery occlusion on NCCT/CTA or MRI/MRA showing occlusion of the intracranial ICA, M1, or proximal M2 vessel
• • 4. Baseline ASPECTS ≥6 or infarct Core Volume of \< 70 on NCCT/DWI/CTP
• • 5. Pre-mRS≤1
• Exclusion Criteria:
• • 1. Any sign of intracranial hemorrhage on baseline CT/MR;
• • 2. Seizures at stroke onset
• • 3. Baseline blood glucose of \<2.78 mmol or \>22.20 mmol, or platelet count \< 100,000/uL or serum creatinine levels \> 3.0 mg/dL
• • 4. Participation in any investigational study in the previous 30 days