Biomarker-Led Optimization of Successful Surgical Outcomes in Moyamoya

Launched by VANDERBILT UNIVERSITY MEDICAL CENTER · Oct 7, 2024

Keywords

ClinConnect Summary

MMD is a condition with narrowing and blockage of major arteries in the brain and people with MMD have a high risk of stroke. Neurosurgical revascularization surgery is usually recommended to provide more blood flow to the brain and hopefully prevent further strokes. The primary goal of this study to improve the understanding of response to neurosurgical treatment and disease improvement or progression by using innovative magnetic resonance imaging (MRI) methods to assess brain blood flow and oxygen use in adults with idiopathic MMD before and after they have surgery.

The study will recrui...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Moyamoya
• • 1. Clinical diagnosis of moyamoya disease as defined by gold-standard catheter angiography and consensus adjudication of imaging and neurological findings
• • 2. Age = 18-60 years
• • 3. Participants for the surgical revascularization aims must be scheduled for clinically indicated indirect surgical revascularization of at least one hemisphere
• • 4. Speak and read English
• • Healthy controls
• • 1. No major medical conditions
• • 2. Age = 18-60 years
• • 3. Speak and read English
• • 4. Able to complete 2 study MRIs and all other study procedures
• Exclusion Criteria:
• • -Both moyamoya and healthy controls
• • 1. History of other major neurological conditions (including but not limited to Parkinson\'s disease, Alzheimer\'s disease, and Multiple Sclerosis) as confirmed by neuroimaging and neurological evaluation (central adjudication committee).
• • 2. History of traumatic brain injury
• • 3. Independent medical condition expected to lead to death within two years.
• • 4. Condition associated with syndromic moyamoya (including but not limited to sickle cell disease, atherosclerosis, neurofibromatosis, Down syndrome).
• • 5. Severe respiratory illness including but not limited to asthma or chronic obstructive pulmonary disease.
• • 7. Contraindication to 3 Tesla MRI 8. Pregnancy