Auditory Research in Children Living With HIV Exposure-uninfected (ARCHIVE)

Launched by SAN DIEGO STATE UNIVERSITY · Oct 8, 2024

Keywords

ClinConnect Summary

The ARCHIVE trial is studying how exposure to antiretroviral therapy (ART) during pregnancy affects the hearing abilities of children who were exposed to HIV but are not infected with the virus themselves. Researchers want to understand if the timing of when mothers start ART during their pregnancies plays a role in their children's hearing. This study is important because it could help improve the health and development of children who were born to mothers living with HIV.

To participate in this trial, children must be healthy infants born after 36 weeks of pregnancy and weighing more than 5.5 pounds at birth. They should not have any major health issues that could affect their development, such as chromosomal disorders or HIV infection. The study is not currently recruiting participants, but when it starts, families who are interested in learning more about their child's hearing and development may find this trial valuable. Participants will likely undergo assessments of their hearing abilities, which can help researchers gather important information.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Healthy infants with delivery at \>36 weeks gestation age
• • Birth weight \>2500g
• • No major chromosomal anomalies, neural tube defects, seizures, HIV infection or other medical conditions that influenced neurodevelopmental outcomes and/or confounded the effects of ART and HIV exposure.
• Exclusion Criteria:
• • Child being older than the proposed age range
• • Caregiver's or the child's refusal to participate