Intravesical Bupivacaine on Post-Operative Ureteroscopy Pain

Launched by UNIVERSITY OF CHICAGO · Oct 8, 2024

Keywords

ClinConnect Summary

This clinical trial is studying the use of a medication called bupivacaine to help reduce pain after a procedure called ureteroscopy, which is used to treat kidney stones. The researchers want to find out if putting bupivacaine in the bladder after the procedure can decrease pain and other uncomfortable symptoms that often happen afterward, compared to using a saltwater solution (normal saline). They believe that using bupivacaine may improve the quality of life for patients in the days following their surgery.

To be part of this study, participants need to be at least 18 years old and diagnosed with kidney stones, and they must be willing to follow the study procedures. However, some people are not eligible, like those with certain medical conditions, a history of allergies to bupivacaine, or those who are pregnant. If eligible, participants can expect to receive either the bupivacaine or the saltwater solution during their bladder treatment after the ureteroscopy and will be monitored for their pain and symptoms afterward. This trial is currently recruiting participants, and everyone involved will be helping to improve care for future patients undergoing similar procedures.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Provision of signed and dated informed consent form
• • Stated willingness to comply with all study procedures and availability for the duration of the study.
• • Male or female, aged ≥ 18 years old.
• • Diagnosis of nephrolithiasis planned for flexible or semi-rigid ureteroscopy in the treatment of stone disease with ureteral stenting.
• Exclusion Criteria:
• • Foley catheterization
• • History of allergy to bupivacaine
• • Antegrade ureteroscopy
• • Transplant or ectopic kidney
• • Ureteral or bladder reconstruction
• • Pregnancy (which is a contraindication to elective ureteroscopy)
• • Dialysis
• • Surgical complication (significant bleeding, ureteral perforation, significant urothelial damage)
• • Suspicion of untreated urinary tract infection
• • History of pelvic radiation
• • Neurologic disease with a diagnosis of neurogenic bladder dysfunction
• • History of chronic pain (fibromyalgia, interstitial cystitis, opioid abuse)