Comparison of Pulmonary Function, Exercise Capacity, and Physical Activity Level Between Children with Hemophilia and Healthy Controls

Launched by HACETTEPE UNIVERSITY · Oct 9, 2024

Keywords

ClinConnect Summary

This clinical trial is studying how children with hemophilia compare to healthy children in terms of lung function, exercise ability, and physical activity levels. Hemophilia is a bleeding disorder that can affect how children move and play, and the study aims to understand how this condition impacts their physical fitness and overall health. The researchers hope to find out if children with hemophilia experience different challenges in breathing and exercising compared to their healthy peers.

To participate, children must be between 8 and 18 years old, diagnosed with hemophilia, and receiving routine preventive treatment. They should also be able to follow instructions during the tests. Healthy children who want to join need to be boys aged 8 to 18 with no known health issues. Participants can expect to undergo various tests to measure their lung function, exercise capacity, and physical activity. This study may help improve how we understand and manage physical activity in children with hemophilia, leading to better health outcomes for them in the future.

Gender

ALL

Eligibility criteria

• • Hemophilia group
• Inclusion criteria:
• • Having been diagnosed with hemophilia and being clinically stable,
• • Being between the ages of 8-18,
• • Being on prophylaxis treatment (a routine treatment),
• • Being 125 cm or taller,
• • Being inhibitor negative at the time of enrollment,
• • To be able to cooperate with the tests to be performed,
• • Being willing to participate in the study.
• Exclusion criteria:
• • Being inhibitor positive at the time of enrollment,
• • Having a history of acute joint bleeding,
• • Being unable to bear weight on the extremities,
• • Having a history of acute intramuscular bleeding,
• • Having undergone radionuclide synovectomy,
• • Having a history of surgery on any of the lower extremity joints,
• • Having a severe cardiovascular, orthopedic or neurological problem that may affect the assessments.
• • Control group
• Inclusion criteria:
• • Not having any known internal or chronic disease
• • Being male between the ages of 8-18
• • Having full range of motion in the upper extremity
• • Having full range of motion in the lower extremity
• • Not having any history of injury or surgery in the lower extremity
• • Being 125 cm or taller
• • Being willing to participate in the study
• Exclusion criteria:
• • Having any problem that may affect the tests
• • Not having full range of motion in the upper extremity
• • Having a history of injury or surgery in any of the lower extremity joints
• • Having a neurological deficit
• • Having pain or movement limitation in the lower extremity