Respiratory Microbioma and Respiratory Complications After Hematopoietic Stem Cell Transplantion

Launched by UNIVERSITY HOSPITAL, CAEN · Oct 10, 2024

Keywords

ClinConnect Summary

This clinical trial is looking to understand the relationship between the respiratory microbiome (the community of viruses and bacteria in our lungs) and respiratory complications that can occur after a treatment called hematopoietic stem cell transplantation (HSCT), which is often used for various blood disorders. Researchers want to find out if the makeup of this microbiome can help predict respiratory issues, both infectious (like pneumonia) and non-infectious (like chronic lung damage), that some patients experience after HSCT. By studying samples from patients, they hope to create a "map" of the respiratory microbiome that could lead to more personalized care and treatment for those at risk of these complications.

To participate in this study, individuals must be 18 or older, speak French, and be receiving care in a hematology department with plans for an HSCT. They should be able to understand the information provided and give their consent to participate. Since the trial is not yet recruiting, interested patients will have the opportunity to learn more about their involvement once it begins. Participants can expect to provide samples for analysis, which may help improve monitoring and treatment strategies for respiratory complications in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Male or female, aged 18 or over
• • French-speaking
• • Followed in the centre's haematology department with a project for a haematopoietic stem cell allograft
• • Whatever the haemopathy, previous treatments, type of transplant (pheno, geno, haplo-identical), type of graft (bone marrow, peripheral stem cells, cord blood), any conditioning (myeloablative or non-myeloablative), any immunosuppressive protocol.
• • Be affiliated to the social security system
• • Person able to understand the information and sign the consent form.
• • Informed consent must be collected and signed
• Exclusion Criteria:
• • Refusal to take part in the research
• • Failure to sign the consent form
• • Contraindication to nasopharyngeal swabbing