Is Preoperative Prediction of Intra-Abdominal Adhesions Possible?

Launched by CELAL BAYAR UNIVERSITY · Oct 10, 2024

Keywords

ClinConnect Summary

This clinical trial is investigating whether certain blood markers can help predict the presence and severity of intra-abdominal adhesions in women who are scheduled for gynecological surgery. Adhesions are bands of scar tissue that can form after previous abdominal surgeries, and they may complicate future operations. The study will involve women aged 18 and older who have had at least one prior cesarean section or abdominal surgery. Participants will be asked to provide blood samples before their surgery, and they will be categorized into two groups: one with adhesions found during surgery and another without adhesions.

If you choose to participate, you will receive both verbal and written information about the study, and your consent will be required. The research team will analyze your blood samples and tissue taken during surgery to see if the levels of specific markers (decorin and TGF β1) can predict the presence and severity of adhesions. The study aims to enroll about 54 participants in total and is currently recruiting. It's important to note that if you are pregnant, have certain health conditions, or do not wish to participate, you will not be eligible for the study.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • Patients who are hospitalized for gynecological reasons with a planned laparotomy or laparoscopic abdominal surgery
• • Patients with at least 1 previous cesarean section or history of previous abdominal surgery (laparoscopy or laparotomy)
• Exclusion Criteria:
• • Patients who do not agree to participate in the study will not be included in the study.
• • Pregnant patients will not be included in the study (so that the physiological changes of pregnancy do not affect the results)
• • Presence of preoperative clinical or laboratory findings of infection (such as high fever, tachycardia, leukocytosis, high CRP)
• • Presence of hematological or coagulation disorders
• • History or presence of cancer treatment
• • History or presence of connective tissue disease
• • Presence of diabetes
• • Being under 18 years of age will be considered as exclusion criteria.