Electrophysiological Signature of Mild Cognitive Impairment and Its Relationship with Parkinson's Disease: a High-density EEG Investigation

Launched by IRCCS SAN CAMILLO, VENEZIA, ITALY · Oct 11, 2024

Keywords

ClinConnect Summary

This clinical trial is studying how mild cognitive impairment (MCI) relates to Parkinson's disease (PD). Researchers want to understand the brain activity patterns in people with PD, especially those who also have MCI, and see how this affects their thinking and movement skills. The study will include 42 participants divided into three groups: healthy individuals, those with PD and MCI, and those with PD but without MCI. Participants will undergo tests to evaluate their cognitive abilities and have their brain activity recorded using a method called high-density electroencephalography (hdEEG) while they are at rest and during specific tasks. This information will help researchers learn more about how the brain functions in people with these conditions.

To be eligible for the trial, participants should be aged between 18 and 89 and have a certain level of cognitive function as indicated by specific tests. They should also be stable on their medications if they are taking any. However, individuals with severe dementia, certain uncontrolled health issues, or those who cannot walk independently will not be able to participate. Those who join can expect to undergo cognitive evaluations and brain activity monitoring, which will contribute to a better understanding of MCI in the context of Parkinson's disease. This study is currently recruiting participants, and everyone who joins will need to sign a consent form to participate.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Upper score \>24 MMSE or \>15.5 Moca
• • If taking medications, taking stable doses for at least 4 weeks prior to the inclusion visit - of anticholinesterase drugs (donepezil, memantine, rivastigmine, ...) or antidepressants (SSRIs, tricyclics, SNARI, ...) or Levodopa.
• • Having signed the informed consent
• Exclusion Criteria:
• • Subjects with severe dementia ( MMSE \< 24 )
• • Lower score \<15.5 Moca
• • Subjects on antipsychotic treatment for less than 3 months
• • Subjects with uncontrolled comorbidities
• • Subjects with metal prostheses or dentures and in general conditions for which MRI examinations are prevented.
• • Subjects with an inability to walk independently.