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Search / Trial NCT06641011

This Study Aims to Evaluate the Effect of Rinsing Off or Blot-drying Silver Fluoride on the Retention of Subsequently-applied Resin- and Glass Ionomer-based Fissure Sealants in Permanent Molars Affected by Molar-Incisor Hypomineralization.

Launched by HACETTEPE UNIVERSITY · Oct 11, 2024

Trial Information

Current as of July 01, 2025

Recruiting

Keywords

Molar Incisor Hypomineralisation Children Silver Fluoride Fissure Sealant Glass Ionomer Silver Modified Atraumatic Restorative Treatment

ClinConnect Summary

This clinical trial is investigating how rinsing off or drying silver fluoride affects the retention of dental sealants on permanent molars in children with a condition called Molar-Incisor Hypomineralization (MIH). MIH can make teeth more susceptible to cavities, so the study aims to see if applying glass ionomer or resin fissure sealants right after or a week after using silver fluoride helps protect these teeth better. Additionally, the trial will check if rinsing or just blotting the silver fluoride has any impact on how well the sealants stay on the teeth, as well as whether these sealants can help with tooth sensitivity.

To participate, children must have at least one permanent molar showing signs of MIH and need to be cooperative during dental procedures. The trial is open to children aged between approximately 2 and 5 years, as long as they don’t have existing cavities, certain dental conditions, or are undergoing orthodontic treatment. Families who choose to participate will be helping researchers understand the best ways to protect young teeth that are at high risk for cavities.

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • Patients and their parents who consent to participate and have signed the informed consent form.
  • Patients with at least one permanent molar diagnosed with molar incisor hypomineralization based on EAPD guidelines.
  • Fully erupted teeth with ICDAS I or II lesions that necessitate the application of fissure sealants.
  • Teeth displaying demarcated opacities on the occlusal surface and at least one additional surface.
  • Exclusion Criteria:
  • Teeth that have existing restorations or cavities.
  • Patients currently receiving orthodontic treatment.
  • Patients who are uncooperative during dental procedures.
  • Teeth affected by dental fluorosis or enamel defects associated with specific syndromes.
  • Children with systemic conditions requiring ongoing medication.

About Hacettepe University

Hacettepe University is a leading research institution in Turkey, renowned for its commitment to advancing medical science and healthcare through innovative clinical research. With a strong emphasis on interdisciplinary collaboration, the university supports a wide range of clinical trials aimed at improving patient outcomes and developing new therapeutic approaches. Hacettepe University is dedicated to maintaining the highest ethical standards and regulatory compliance in its research endeavors, fostering an environment that promotes scientific excellence and contributes to the global body of medical knowledge.

Locations

Ankara, , Turkey

Patients applied

0 patients applied

Trial Officials

Elif Ballikaya, DDS, PhD

Principal Investigator

Hacettepe University

Zafer Cehreli, DDS, PhD

Principal Investigator

Hacettepe University

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported