Creating a Global Research Database That Connects Genetic Information and Long-term Health Data to Improve Personalized Treatment for People with Serious Mental Illness

Launched by AKRIVIA HEALTH · Oct 11, 2024

Keywords

ClinConnect Summary

This clinical trial is focused on understanding serious mental illnesses like bipolar disorder, schizophrenia, major depressive disorder, and dementia. Researchers aim to collect information and samples from over 50,000 participants to link this data with their health records and genetic information. By doing this, they hope to identify how various factors—such as genetics and life circumstances—affect the experiences and health outcomes of people living with these conditions. Ultimately, this study aims to improve diagnosis and develop more effective treatments for mental health issues.

To participate, individuals need to be at least 18 years old and have a health record demonstrating a diagnosis or treatment for one of the targeted mental health conditions or dementia. Participants should be able to understand and speak English. Those who join can expect to share their health information and biological samples and complete a cognitive assessment. This trial is not yet recruiting participants, but it will contribute valuable insights to the broader field of mental health research. Additionally, the data collected will be shared with other researchers to help further advance treatment options for these challenging conditions.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • - All participants must have an electronic health record in a primary or secondary care service.
• • Mental Health cohort(s) • Have received a diagnosis and/or treatment/referral for mental illness for MDD, BD, Schizophrenia.
• • • Having an available electronic health record
• • • Current age 18+ (no upper age limit)
• • • Can speak English Dementia cohort
• • • Participants aged 18+ (no upper age limit)
• • • Currently alive and are, or have been, old age psychiatry patients
• • •
• Received relevant diagnosis or referral:
• • EITHER
• • • Clinical diagnosis of dementia, mild cognitive impairment (MCI) or subjective cognitive impairment (SCI) OR
• • • Memory clinic referral
• • • Must be willing and able to complete a validated cognitive assessment (MoCA or SLUMS).
• • All dementia patients will undergo the extended biomarker analysis.
• Exclusion Criteria:
• • - Mental Health cohort(s)
• • • Patients without capacity to provide consent. Dementia cohort
• • • Inability to understand spoken and/or written spoken English
• • • Individuals with intellectual disability.
• • • Patients with dementia in Creutzfeldt-Jakob disease (CJD), Huntington's, HIV dementia, alcohol-related dementia, intellectual disability, traumatic brain injury at any time.
• • • Patients diagnosed with depression (only an exclusion criterion for MCI/SCI patients), psychosis, bipolar disorder prior in the pre-index period - to be checked at screening.