CGM Dynamic Index for Predicting Prediabetes in Cystic Fibrosis

Launched by INDIANA UNIVERSITY · Oct 11, 2024

Keywords

ClinConnect Summary

This clinical trial is focused on understanding how to predict the progression from prediabetes to diabetes in people with cystic fibrosis (CF). Researchers want to create a model that uses data from a continuous glucose monitoring (CGM) system, which tracks blood sugar levels over time. The goal is to help identify CF patients who may be at risk of developing diabetes, allowing for earlier interventions.

To participate in this study, individuals must be between the ages of 12 and 55 and have cystic fibrosis without diabetes, or they may have prediabetes based on specific blood tests. Participants will need to be comfortable using a CGM device that connects to a smartphone to collect their glucose data. Those already using a CGM will simply provide their existing data. It’s important to note that individuals who are pregnant, have had a transplant, or are on certain medications that affect blood sugar levels cannot participate. This study is not yet recruiting participants, but it aims to improve health outcomes for those living with cystic fibrosis.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • CF individuals aged 12-55 years.
• • CF without diabetes or with prediabetes (as defined by OGTT and HbA1c).
• • Willing to use a continuous glucose monitoring system with compatible smart phone for glucose data collection.
• • A person with CFRD and already using CGM, we will just collect their personal CGM data, and they are not required to have OGTT or HbA1c visit.
• Exclusion Criteria:
• • Pregnancy.
• • History of transplant.
• • Use of immunosuppressant drugs.
• • Use of oral steroids or any medication known to interfere with glucose.
• • Allergy to adhesives.
• • Individuals with severe concurrent medical conditions that could confound glucose monitoring data (e.g., terminal illness, major organ failure).
• • Conditions that may make unsafe for participants to do study or impair or confound the study at the discretion of the investigator