Tranilast Vs. Steroids to Prevent Esophageal Stricture (TAPES) After Endoscopic Resection for Superficial Neoplasms
Launched by SECOND AFFILIATED HOSPITAL, SCHOOL OF MEDICINE, ZHEJIANG UNIVERSITY · Oct 15, 2024
Trial Information
Current as of June 26, 2025
Not yet recruiting
Keywords
ClinConnect Summary
The TAPES clinical trial is studying whether a medication called tranilast can help prevent a condition known as esophageal stricture, which can occur after a specific type of treatment for certain esophageal growths called superficial neoplasms. In this trial, researchers will compare tranilast to prednisone, a common steroid, to see which one is more effective at preventing esophageal stricture and to learn about any potential side effects of tranilast.
To participate, individuals must be at least 18 years old, speak Mandarin, and have recently undergone a specific treatment called circumferential endoscopic submucosal dissection (cESD) for their esophageal condition. Participants will take either tranilast or prednisone daily for eight weeks and will have regular check-ups every two weeks for 16 weeks to monitor their health and any symptoms they experience. This trial is currently not recruiting participants, but it's an important step in understanding better treatment options for those at risk of esophageal stricture.
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • 1. age\>18 and proficient in Mandarin.
- • 2. underwent cESD treatment for superficial esophageal neoplasms.
- • 3. agree to sign an informed consent form.
- Exclusion Criteria:
- • 1. allergic to tranilast.
- • 2. with severe comorbid conditions.
- • 3. pregnant or breastfeeding.
About Second Affiliated Hospital, School Of Medicine, Zhejiang University
The Second Affiliated Hospital of Zhejiang University School of Medicine is a leading clinical research institution dedicated to advancing healthcare through innovative medical practices and rigorous scientific inquiry. With a robust infrastructure and a multidisciplinary team of experienced researchers and clinicians, the hospital is committed to conducting high-quality clinical trials that address critical health challenges. As an integral part of Zhejiang University, the hospital leverages academic expertise and cutting-edge technology to foster collaboration in research, education, and patient care, ultimately aiming to improve patient outcomes and contribute to the global medical community.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Hangzhou, Zhejiang, China
Hangzhou, Zhejiang, China
Shaoxing, Zhejiang, China
Patients applied
Trial Officials
Yue Yu, Dr.
Principal Investigator
Second Affiliated Hospital, School of Medicine, Zhejiang University
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported