Correlation Between Gut Microbiota and Pancreatic Β-Cell Function in Diabetic Patients

Launched by PEKING UNIVERSITY THIRD HOSPITAL · Oct 15, 2024

Keywords

ClinConnect Summary

1. Research Objective: This study aims to explore the differences in gut microbiota and their metabolites, as well as gene function differences, between young and elderly individuals under different glucose metabolism states. The goal is to screen for specific bacterial species or metabolites with significant differences and examine their correlation with pancreatic β-cell function.
2. Research Design

2.1 Study Subjects: Young and elderly subjects with different glucose metabolism states will be recruited from the community or the outpatient department of Peking University Third Hospital b...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age: Young (18 \< age \< 45 years) and elderly (age ≥ 65 years) subjects;
• • Individuals with different glucose metabolism states, including normal glucose metabolism, pre-diabetes, and diabetes, without gastrointestinal diseases or a history of gastrointestinal surgery (such as active gastrointestinal inflammation or bleeding, inflammatory bowel disease, etc.), without cognitive impairment, without tumors, and without chronic respiratory diseases (such as chronic obstructive pneumonia, asthma, etc.), and not on a special diet (e.g., vegetarians).
• Exclusion Criteria:
• • Use of antibiotics or health supplements within the last month.
• • Diarrhea within the last 2 weeks: bowel movements ≥3 times/24 hours, with changes in stool consistency.
• • Constipation within the last 2 weeks (based on the Rome III criteria for functional constipation).
• • Acute complications of diabetes, such as diabetic ketoacidosis, within the last 3 months.
• • History of gastrointestinal diseases or gastrointestinal surgery.
• • Cognitive impairment.
• • History of tumors.
• • Special diet (e.g., vegetarians).