The Gut Microbiota and Metabolites in HFpEF

Launched by THE FIRST AFFILIATED HOSPITAL WITH NANJING MEDICAL UNIVERSITY · Oct 15, 2024

Keywords

ClinConnect Summary

1. Heart failure with preserved ejection fraction is an urgent clinical challenge As the leading killer of human life and health, cardiovascular disease is a difficult public health problem worldwide. According to the latest statistics of China Cardiovascular Health and Disease Report 2022, the number of patients in China has exceeded 330 million, and the number of patients with heart failure (HF) is as high as 8.9 million, becoming the second leading cause of death related to heart disease after coronary heart disease. According to the 2023 European Society of Cardiology (ESC) guidelines f...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Male or female, ≥18 years old;
• • 2. With symptoms and signs of chronic heart failure, NYHA class II-IV;
• • 3. LVEF≥50% according to the most recent echocardiography before screening, and no previous record of LVEF\<50%;
• • 4. BNP \>35 pg/mL, or NT-proBNP \>125 pg/mL;
• 5. Comply with at least one of the following:
• • (1) LVMI ≥ 115g/m2 (men) 95g/m2 (women); (2) RWT \> 0.42; R (3) E/e '\>15; (4) septal e '\<7cm/s or lateral e' \<10cm/s or mean e '\<8cm/s; (5) TVR\>2.8m/s or PASP\>35mmHg.
• Exclusion Criteria:
• • Patients with confirmed chronic or acute renal insufficiency (stage II-IV)