A Study to Compare the Efficacy and Safety of BMS-986489 (BMS-986012+ Nivolumab Fixed Dose Combination) in Combination With Carboplatin Plus Etoposide to That of Atezolizumab With Carboplatin Plus Etoposide as First-Line Therapy in Participants With Extensive-Stage Small Cell Lung Cancer (TIGOS).
Launched by BRISTOL-MYERS SQUIBB · Oct 16, 2024
Trial Information
Current as of June 12, 2025
Recruiting
Keywords
ClinConnect Summary
This clinical trial, called TIGOS, is studying a new treatment for people with Extensive-Stage Small Cell Lung Cancer (ES-SCLC). The researchers want to compare two treatment combinations: one that includes a drug called BMS-986489 along with carboplatin and etoposide, and another that uses atezolizumab with the same chemotherapy drugs. The goal is to see which combination works better and is safer for patients starting their treatment.
To participate in this study, individuals must have a confirmed diagnosis of ES-SCLC and be healthy enough to carry out their daily activities with minimal assistance. They should also have at least one measurable tumor that can be seen through imaging tests like a CT scan. However, those who have previously received certain treatments for this type of cancer or have specific health issues, such as symptoms related to cancer spread in the brain or significant heart problems, may not be eligible. If you qualify and choose to participate, you'll receive close medical supervision and be part of an important effort to find better treatment options for lung cancer.
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Participants must have diagnosis of Extensive-Stage Small Cell Lung Cancer (ES-SCLC).
- • Participants must be Healthy enough to do their normal activities with little or no help based on the ECOG performance scale.
- • Participants must have at least one tumor that can be measured using special imaging techniques like a CT scan or MRI at a site other than the brain and nervous system
- Exclusion Criteria:
- • Participants have already received certain types of treatment for extensive stage small cell lung cancer
- • Participants have certain health conditions, like spread of small cell lung cancer to the brain that are causing symptoms, certain lung diseases, heart diseases, infections, autoimmune diseases, other cancers, or a type of nerve damage called peripheral sensory neuropathy
- • Other protocol-defined Inclusion/Exclusion criteria apply.
About Bristol Myers Squibb
Bristol-Myers Squibb (BMS) is a global biopharmaceutical company dedicated to discovering, developing, and delivering innovative medicines that help patients prevail over serious diseases. With a robust portfolio of products across multiple therapeutic areas, including oncology, immunology, cardiovascular, and fibrotic diseases, BMS emphasizes cutting-edge research and a commitment to advancing medical science through clinical trials. The company is driven by a mission to provide transformative therapies, leveraging collaboration and scientific expertise to address unmet medical needs and improve patient outcomes worldwide.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Penrith, New South Wales, Australia
Groningen, , Netherlands
Aberdeen, , United Kingdom
Seattle, Washington, United States
Peoria, Illinois, United States
Cincinnati, Ohio, United States
Hamamatsu, Shizuoka, Japan
Sevilla, , Spain
Zürich, , Switzerland
Kurume, Fukuoka, Japan
Albuquerque, New Mexico, United States
Kanazawa, Ishikawa, Japan
Kurashiki, Okayama, Japan
Paris, , France
Bunkyo Ku, Tokyo, Japan
Manchester, , United Kingdom
Chur, , Switzerland
Winterthur, , Switzerland
Shanghai, , China
Marietta, Georgia, United States
Fukushima, , Japan
Matsuyama, Ehime, Japan
Graz, Steiermark, Austria
Sapporo, Hokkaido, Japan
Milano, , Italy
Hidaka, Saitama, Japan
Yokohama, Kanagawa, Japan
Quebec, , Canada
Shantou, Guangdong, China
Saint Petersburg, Florida, United States
Linhai, Zhejiang, China
Chengdu, Sichuan, China
Jinan, Shandong, China
Murdoch, Western Australia, Australia
Albuquerque, New Mexico, United States
Grosshansdorf, , Germany
Oldenburg, Niedersachsen, Germany
Hirakata, Osaka, Japan
Wirral, , United Kingdom
Sioux Falls, South Dakota, United States
Brno, Brno Město, Czechia
Orange City, Florida, United States
Linz, , Austria
Madrid, Community Of Madrid, Spain
Rankweil, , Austria
Roanoke, Virginia, United States
Fort Myers, Florida, United States
Kobe Shi, Hyogo, Japan
Pierre Bénite, Rhône, France
Chongqing, Chongqing, China
Tyler, Texas, United States
Craiova, Dolj, Romania
Madrid, Madrid, Comunidad De, Spain
Takatsuki, Osaka, Japan
Wels, Oberösterreich, Austria
Thessaloniki, Thessaloníki, Greece
Napoli, Campania, Italy
łódź, łódzkie, Poland
Hot Springs, Arkansas, United States
Frankfurt, Hessen, Germany
Konin, Wielkopolskie, Poland
Chicoutimi, Quebec, Canada
Xi'an, Shaanxi, China
Barcelona, Catalunya [Cataluña], Spain
Skorzewo, Wielkopolskie, Poland
Barcelona, Catalunya [Cataluña], Spain
Santiago De Compostela, A Coruña [La Coruña], Spain
Koto, Tokyo, Japan
Valencia, Valenciana, Comunitat, Spain
Villejuif, Val De Marne, France
La Tronche, Isère, France
Caba, Ciudad Autónoma De Buenos Aires, Argentina
Marietta, Georgia, United States
Majadahonda, Madrid, Comunidad De, Spain
Ballarat Central, Victoria, Australia
Río Cuarto, Córdoba, Argentina
Rome, Roma, Italy
Hangzhou, Zhejiang, China
Athens, Attikí, Greece
Montpellier, Hérault, France
Marseille, , France
Prabuty, Pomorskie, Poland
Viña Del Mar, Valparaíso, Chile
Créteil, Val De Marne, France
Gauting, , Germany
Nashville, Tennessee, United States
Nashville, Tennessee, United States
Abb, Ciudad Autónoma De Buenos Aires, Argentina
Cluj, , Romania
Santiago, Región Metropolitana De Santiago, Chile
Rimouski, Quebec, Canada
Lille Cedex, Nord, France
Halle, Sachsen Anhalt, Germany
Bucharest, București, Romania
Köln, Nordrhein Westfalen, Germany
Santiago, Región Metropolitana De Santiago, Chile
Ciudad Autónoma De Buenos Aires, Buenos Aires, Argentina
Iași, , Romania
Brisbane, Queensland, Australia
Iași, , Romania
Santiago, Región Metropolitana De Santiago, Chile
Fort Myers, Florida, United States
Orange City, Florida, United States
Saint Petersburg, Florida, United States
Minneapolis, Minnesota, United States
Albuquerque, New Mexico, United States
Durham, North Carolina, United States
Cincinnati, Ohio, United States
Sioux Falls, South Dakota, United States
Knoxville, Tennessee, United States
Austin, Texas, United States
Tyler, Texas, United States
Blacksburg, Virginia, United States
Seattle, Washington, United States
Tacoma, Washington, United States
Ciudad Autónoma De Buenos Aires, Buenos Aires, Argentina
Abb, Ciudad Autónoma De Buenos Aires, Argentina
Buenos Aires, Ciudad Autónoma De Buenos Aires, Argentina
Caba, Ciudad Autónoma De Buenos Aires, Argentina
Río Cuarto, Córdoba, Argentina
Campbelltown, New South Wales, Australia
Penrith, New South Wales, Australia
Brisbane, Queensland, Australia
Ballarat Central, Victoria, Australia
Murdoch, Western Australia, Australia
Wels, Oberösterreich, Austria
Graz, Steiermark, Austria
Linz, , Austria
Rankweil, , Austria
Wien, , Austria
Gent, Oost Vlaanderen, Belgium
Sint Niklaas, Oost Vlaanderen, Belgium
Leuven, Vlaams Brabant, Belgium
Liège, , Belgium
Fortaleza, Ceará, Brazil
Porto Alegre, Rio Grande Do Sul, Brazil
Porto Alegre, Rio Grande Do Sul, Brazil
Santa Cruz Do Sul, Rio Grande Do Sul, Brazil
Itajaí, Santa Catarina, Brazil
Barretos, São Paulo, Brazil
Sao Paulo, São Paulo, Brazil
Edmonton, Alberta, Canada
Chicoutimi, Quebec, Canada
Rimouski, Quebec, Canada
Quebec, , Canada
Santiago, Región Metropolitana De Santiago, Chile
Santiago, Región Metropolitana De Santiago, Chile
Santiago, Región Metropolitana De Santiago, Chile
Santiago, Región Metropolitana De Santiago, Chile
Viña Del Mar, Valparaíso, Chile
Brno, Brno Město, Czechia
Ostrava, Ostrava Město, Czechia
Prague, Praha 4, Czechia
Olomouc, , Czechia
Montpellier, Hérault, France
La Tronche, Isère, France
Lille, Nord Pas De Calais, France
Gleize, Rhône, France
Pierre Bénite, Rhône, France
Créteil, Val De Marne, France
Villejuif, Val De Marne, France
Marseille, , France
Paris, , France
Quimper, , France
Frankfurt, Hessen, Germany
Oldenburg, Niedersachsen, Germany
Köln, Nordrhein Westfalen, Germany
Halle, Sachsen Anhalt, Germany
Bad Berka, Thüringen, Germany
Berlin, , Germany
Gauting, , Germany
Grosshansdorf, , Germany
Stuttgart, , Germany
Athens, Attikí, Greece
Athens, Attikí, Greece
Thessaloniki, Kentrikí Makedonía, Greece
Thessaloniki, Thessaloníki, Greece
Larissa, Thessalía, Greece
New Delhi, Delhi, India
Bengaluru, Karnataka, India
Madurai, Tamil Nadu, India
Varanasi, Uttar Pradesh, India
Kolkata, West Bengal, India
Napoli, Campania, Italy
Milan, Lombardia, Italy
Rome, Roma, Italy
Perugia, Umbria, Italy
Peschiera Del Garda, Verona, Italy
Bologna, , Italy
Milano, , Italy
Amsterdam, Noord Holland, Netherlands
Arnhem, , Netherlands
Groningen, , Netherlands
Prabuty, Pomorskie, Poland
Konin, Wielkopolskie, Poland
Skorzewo, Wielkopolskie, Poland
Bydgoszcz, , Poland
łódź, łódzkie, Poland
Bucuresti, București, Romania
Florești, Cluj, Romania
Craiova, Dolj, Romania
Craiova, Dolj, Romania
București, , Romania
Cluj, , Romania
Iași, , Romania
Iași, , Romania
Barcelona, Catalunya [Cataluña], Spain
Barcelona, Catalunya [Cataluña], Spain
Jaen, Jaén, Spain
Madrid, Madrid, Comunidad De, Spain
Chur, , Switzerland
Winterthur, , Switzerland
Zürich, , Switzerland
Cigli, İzmir, Turkey
Adana, , Turkey
Ankara, , Turkey
Ankara, , Turkey
Istanbul, , Turkey
London, London, City Of, United Kingdom
Central Middlesbrough, Middlesbrough, United Kingdom
Aberdeen, , United Kingdom
Leicester, , United Kingdom
Manchester, , United Kingdom
Bucharest, București, Romania
Brussels, Bruxelles Capitale, Région De, Belgium
Quebec, , Canada
Chongqing, Chongqing, China
Matsuyama, Ehime, Japan
Kurume, Fukuoka, Japan
Sapporo, Hokkaido, Japan
Kobe, Hyogo, Japan
Kanazawa, Ishikawa, Japan
Yokohama, Kanagawa, Japan
Sendai, Miyagi, Japan
Kashihara, Nara, Japan
Kurashiki, Okayama, Japan
Hirakata, Osaka, Japan
Osakasayama, Osaka, Japan
Takatsuki, Osaka, Japan
Hidaka, Saitama, Japan
Ina Machi, Saitama, Japan
Hamamatsu, Shizuoka, Japan
Bunkyo Ku, Tokyo, Japan
Koto, Tokyo, Japan
Fukushima, , Japan
Cheongju Si, Chungcheongbuk Do [Chungbuk], Korea, Republic Of
Seongnam, Kyǒnggi Do, Korea, Republic Of
Suwon Si, Kyǒnggi Do, Korea, Republic Of
Seoul, Seoul Teukbyeolsi [Seoul], Korea, Republic Of
Seoul, Seoul Teukbyeolsi [Seoul], Korea, Republic Of
Daegu, Taegu Kwangyǒkshi, Korea, Republic Of
Valencia, Valenciana, Comunitat, Spain
Wirral, , United Kingdom
Austin, Texas, United States
Xi'an, Shaanxi, China
Roanoke, Virginia, United States
Brisbane, Queensland, Australia
Beijing, Beijing, China
Santiago, Región Metropolitana De Santiago, Chile
Beijing, Beijing, China
Fuzhou, Fujian, China
Xiamen, Fujian, China
Shantou, Guangdong, China
Harbin, Heilongjiang, China
Wuhan, Hubei, China
Wuhan, Hubei, China
Changsha, Hunan, China
Nanchang, Jiangxi, China
Changchun, Jilin, China
Shenyang, Liaoning, China
Jinan, Shandong, China
Shanghai, Shanghai, China
Shanghai, Shanghai, China
Chengdu, Sichuan, China
Tianjin, Tianjin, China
Hangzhou, Zhejiang, China
Hangzhou, Zhejiang, China
Linhai, Zhejiang, China
Shanghai, , China
Heidelberg, , Germany
Kuching, Sarawak, Malaysia
Kuala Lumpur, Wilayah Persekutuan Kuala Lumpur, Malaysia
Kuala Lumpur, Wilayah Persekutuan Kuala Lumpur, Malaysia
Pachuca, Hidalgo, Mexico
Guadalajara, Jalisco, Mexico
Monterrey, Nuevo León, Mexico
Puebla, , Mexico
Bucharest, București, Romania
Bucharest, București, Romania
Santiago De Compostela, A Coruña [La Coruña], Spain
Madrid, Madrid, Comunidad De, Spain
Majadahonda, Madrid, Comunidad De, Spain
Sevilla, , Spain
Sevilla, , Spain
Sendai, Miyagi, Japan
Ostrava, Ostrava Město, Czechia
Shantou, Guangdong, China
Lille Cedex, Nord, France
Hot Springs, Arkansas, United States
Gleize, Rhône, France
Stuttgart, , Germany
Peschiera Del Garda, Verona, Italy
Kashihara City, Nara, Japan
Florești, Cluj, Romania
Jaen, Jaén, Spain
Cleveland, Ohio, United States
Campbelltown, New South Wales, Australia
Quimper, , France
Daphne, Alabama, United States
Bunkyo Ku, Tokyo, Japan
Poznań, Wielkopolskie, Poland
Bydgoszcz, , Poland
Patients applied
Trial Officials
Bristol-Myers Squibb
Study Director
Bristol-Myers Squibb
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported