Radiolabelled Nectin-4 Targeted LMW Probe PET/CT in Patients With Lung Lesions

Launched by PEKING UNIVERSITY CANCER HOSPITAL & INSTITUTE · Oct 16, 2024

Keywords

ClinConnect Summary

This clinical trial is studying a special imaging test using a substance called [68Ga]N188 to see how well it can detect a protein called nectin-4 in patients with lung lesions, which could be related to lung cancer or infections. The main goal is to find out if this test can help doctors identify and better understand these lung issues. The trial is currently looking for participants aged 18 to 75 who have normal heart function, are expected to live for at least 12 weeks, and have at least one measurable lung lesion that can be tracked.

Participants will need to sign an informed consent form, meaning they fully understand what the study involves. If you are a woman who can get pregnant, you will need to take a pregnancy test and agree to use contraception during the study. You should also be able to lie still for about half an hour for the imaging test. However, if you have serious liver or kidney problems, are pregnant or breastfeeding, or have certain mental health conditions, you may not be eligible to join the trial. Overall, this study aims to improve how doctors diagnose and treat lung-related issues.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. 18-75 years old, male or female;
• • 2. Heart function is normal;
• • 3. Normal heart function;
• • 4. Estimated survival ≥12 weeks;
• • 5. Good follow-up compliance;
• • 6. presence of at least one measurable target lesion according to RECIST1.1 criteria;
• • 7. Women of childbearing age (15-49 years) must have a negative pregnancy test within 7 days before starting the test; Fertile men and women must agree to use effective contraception to prevent pregnancy during the study period and for 3 months after the test;
• • 8. Patients recommended by clinicians to undergo PET/CT examination for tumor diagnostic staging;
• • 9. The subject patients could fully understand and voluntarily participate in the experiment, and signed the informed consent.
• Exclusion Criteria:
• • 1. Serious abnormality of liver, kidney and blood;
• • 2. Pregnant patients;
• • 3. Pregnant and lactation women;
• • 3) unable to lie flat for half an hour; 4) Refuse to join the clinical investigator; 5) Suffering from claustrophobia or other mental diseases; 6) Other conditions that researchers deem unsuitable for participating in the experiment.