Study of LM-299 in Subjects Advanced Malignant Tumors

Launched by LANOVA MEDICINES LIMITED · Oct 17, 2024

Keywords

ClinConnect Summary

This clinical trial is studying a new treatment called LM-299 for patients with advanced malignant tumors, which are types of cancer that have spread and are difficult to treat. The main goal of the study is to find out how safe LM-299 is, determine the highest dose that patients can tolerate, and identify the best dose to use in future studies. The trial is currently looking for participants aged 18 and older who are in relatively good health, have a life expectancy of at least three months, and have at least one measurable tumor.

To be eligible, potential participants should have a performance status that indicates they can carry out daily activities with minimal issues. They should also be able to provide a sample of their tumor tissue for testing. It's important to note that people with certain health issues, like severe pain from their cancer or recent serious infections, may not qualify. If you choose to participate, you will have close monitoring throughout the trial to ensure your safety and help researchers learn more about how well LM-299 works.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Subjects who are willing to participate in the study and sign the informed consent form (ICF) prior to any procedure.
• • 2. Participant must be 18- 18 years or the legal age of consent at the time of signing the ICF.
• • 3. Eastern Cooperative Oncology Group (ECOG) performance status of 0-1.
• • 4. Life expectancy ≥ 3 months.
• • 5. Patients with advanced solid tumors confirmed by histopathological diagnosis who have failed standard treatment, are intolerant to standard treatment, or for whom standard treatment is currently unsuitable.
• • 6. Pre-treatment archived tumour tissue (within 5 years) or fresh samples could be provided for biomarker analysis.
• • 7. Must have at least one measurable lesion according to RECIST v1.1.
• • 8. Adequate organ and bone marrow function as defined by protocol.
• • 9. Female subjects of childbearing potential or male subjects with partners of childbearing potential agree to use highly effective contraception.
• • 10. Subjects who are able to communicate well with investigators and understand and adhere to the requirements of this study.
• Exclusion Criteria:
• • 1. Participate in any other clinical trial within 28 days prior to 1st dosing of LM-299.
• • 2. Subjects who have received the anti-tumor treatments within the specified time periods prior to the first dosing of LM-299.
• • 3. Any adverse event from prior anti-tumour therapy has not yet recovered to ≤ grade 1 of CTCAE v5.0.
• • 4. Subjects with uncontrolled tumour-related pain.
• • 5. Subjects with known central nervous system (CNS) or meningeal metastasis.
• • 6. Qualitative urine protein results ≥ 3+.
• • 7. Clinically significant hemoptysis or tumor bleeding within 2 weeks prior to 1st dosing of LM-299.
• • 8. Any life-threatening bleeding event that occurred within 3 months prior to 1st dosing of LM-299.
• • 9. Subjects with esophageal or gastric varices requiring immediate intervention or a history of variceal bleeding .
• • 10. Hepatic encephalopathy, hepatorenal syndrome, or Child-Pugh class B or more severe liver cirrhosis.
• • 11. Subjects who have clinically uncontrollable third-space fluid accumulatio.
• • 12. Radiographic evidence of tumor invading surrounding vital organs or the risk of esophagotracheal fistula or esophagopleural fistula, tumor surrounding or invading the major blood vessels, or presence of intratumoral cavity formation.
• • 13. History of gastrointestinal perforation and/or fistula within 6 months prior to the first dose of the study drug.
• • 14. Patients with complete or incomplete intestinal obstruction within 3 months prior to the first dose of the study drug or patientswho are currently at the risk of intestinal perforation.
• • 15. Subjects who are known to be allergic to antibody treatment.
• • 16. Subjects who take systemic corticosteroids (≥ 10 mg/day of prednisone or equivalent) for more than 7 days within 2 weeks prior to the first dose of LM-299.
• • 17. Subjects with the known history of autoimmune disease.
• • 18. Patients with a history of active or previously confirmed inflammatory bowel disease.
• • 19. Patients with a history of or currently having interstitial pneumonia requiring systemic corticosteroid treatment.
• • 20. Received live vaccines or attenuated live vaccines within 28 days prior to the first dose of the study drug.
• • 21. Currently using anticoagulants such as therapeutic doses of heparin or vitamin K antagonists.
• • 22. Subjects who received major surgery or interventional treatment within 28 days prior to 1st dosing of LM-299 (excluding tumour biopsy, puncture, etc.).
• • 23. Subjects who have severe cardiovascular and and cerebrovascular diseases.
• • 24. Patients with severe infections within 4 weeks prior to the first dose.
• • 25. Patients with a history of immunodeficiency.
• • 26. Individuals with HIV infection, active HBV or HCV infection .
• • 27. Patients with known active tuberculosis (TB). Suspected active TB should be ruled out through clinical examination.
• • 28. Patients who have had other malignancies within 5 years prior to the first dose of the study drug.
• • 29. Women of childbearing age who test positive for pregnancy within 7 days prior to the first dose of the study drug or are breastfeeding.
• • 30. Individuals with known psychiatric disorders or illnesses that may affect adherence to the trial.
• • 31. Patients with local or systemic diseases caused by non-malignant tumors.
• • 32. Subject who is judged as not eligible to participate in this study by the investigator.