Pharmacokinetics of Oral Calcium Carbonate in Parturients

Launched by STANFORD UNIVERSITY · Oct 18, 2024

Keywords

ClinConnect Summary

This clinical trial is studying how calcium levels in the blood change after pregnant women take a common antacid called calcium carbonate, often found in products like "Tums." The goal is to understand these changes better because researchers are exploring whether calcium might help reduce heavy bleeding after childbirth, known as postpartum hemorrhage.

To be eligible for this study, participants need to be pregnant women who are admitted to the hospital for labor. However, there are some important criteria: women aged 18 to 45, those without severe blood pressure issues, and those not taking certain medications that could interfere with the study. If you join the trial, you’ll take a dose of calcium carbonate, and the researchers will monitor how your calcium levels in the blood change over time. This information could help improve care for women during and after delivery.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • Pregnant female subjects at the study institution, admitted for labor (spontaneous, augmented, or induced)
• Exclusion Criteria:
• • 1. severe range blood pressure (BP \>160/\>110) within the 48 hours prior to delivery
• • 2. patient age \<18 years or \>45 years
• • 3. renal dysfunction with a documented serum Cr \> 1.0 mg/dL
• • 4. known history of congenital or acquired cardiac disease or history of arrhythmia
• • 5. patient taking digoxin
• • 6. patient currently taking a calcium channel blocker
• • 7. Weight \<55kg or \>100kg, or
• • 8. receiving magnesium infusion within 24 hours prior to or during cesarean delivery
• • 9. Prior or planned administration of calcium by the obstetric or anesthesiology teams for clinical indications within 24 hours of study enrollment
• • 10. Patient took a calcium supplement in the past 48 hours
• • 11. Patient status is NPO (nothing by mouth) as ordered by the clinical team