AlEX-DHF: Ablation and Exercise in Diastolic Heart Failure

Launched by TECHNICAL UNIVERSITY OF MUNICH · Oct 18, 2024

Keywords

ClinConnect Summary

The AlEX-DHF clinical trial is studying how a combination of exercise and a procedure called ablation can help people with heart failure with preserved ejection fraction (HFpEF) and short-persistent atrial fibrillation (Afib). Researchers believe that this combination can improve how well the heart and body use oxygen during exercise, making everyday activities easier for patients. The exercise part of the study includes a 12-week program with video-based training that focuses on endurance, strength, and breathing exercises.

To participate in this trial, individuals should be diagnosed with HFpEF and have experienced symptoms of short-persistent Afib within the last year. Unfortunately, those with certain heart conditions, previous ablation therapy, or other serious health issues will not be eligible. Participants can expect to be part of a supportive exercise program while also receiving the ablation procedure, which aims to help manage their heart condition better. This trial is currently recruiting participants aged between 65 and 74, and aims to improve the quality of life for those affected by these heart issues.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Diagnosed heart failure with preserved ejection fraction
• • Symptomatic short-persistent atrial fibrillation (diagnosis within 1 year of study inclusion)
• Exclusion Criteria:
• • Paroxysmal, long-persistent or permanent atrial fibrillation
• • Clinically unstable coronary artery disease or acute coronary syndrome
• • Physical and/or mental inability to perform exercise testing
• • Prior ablation therapy
• • Precapillary pulmonary hypertension at rest
• • Intracardiac shunts
• • Left ventricular ejection fraction \<50%
• • High-degree valve insufficiency or stenosis (greater than grade 1 at rest)