Hemodynamic Effects of a High Dose Versus Low Dose Propofol During Induction of Anesthesia.

Launched by AIN SHAMS UNIVERSITY · Oct 19, 2024

Keywords

ClinConnect Summary

This clinical trial is studying the effects of two different doses of a medication called Propofol, which is commonly used to help patients go to sleep during surgery. Researchers want to find out how a high dose of Propofol compares to a low dose in terms of how it affects the heart and blood flow when anesthesia is started. The trial is currently recruiting participants who are between 21 and 40 years old and are scheduled for elective surgery.

To be eligible, participants need to be in good health (classified as ASA I or II), meaning they have no serious medical conditions that could complicate the surgery or anesthesia. Unfortunately, individuals with certain health issues, such as severe obesity, uncontrolled high blood pressure, or significant heart, liver, or kidney problems, won’t be able to participate. Those who join the trial can expect to be closely monitored during the anesthesia process to see how their bodies respond to the different doses of Propofol. This study aims to improve our understanding of how anesthesia affects patients, which can lead to safer surgical experiences in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Age: from 21 years old till 40 years old.
• • 2. Patients with ASA classification I and II.
• • 3. Undergoing a scheduled elective surgery.
• Exclusion Criteria:
• • 1. Declining to give written informed consent.
• • 2. ASA classification III-V.
• • 3. Patients with class III (morbid) obesity or more (BMI \>40 Kg/m2)
• • 4. Patients with severe intraoperative hypotension requiring large volume of intravascular fluid treatment.
• • 5. Severe or uncontrolled hypertension (NIBP\> 150/100) , congestive heart failure, moderate to severe valvular heart disease , uncontrolled arrhythmia , heart rate\>100bpm .
• • 6. Significant hepatic or renal disorder.
• • 7. Patients with uncontrolled diabetes mellitus type 1 or type 2(evidenced by autonomic dysfunction or organ complications, ischemic heart disease or cerebrovascular disease).
• • 8. Patients who were pregnant (positive pregnancy test) or menstruating.
• • 9. Anemia with hemoglobin level \<9.0 g/dL
• • 10. Hypersensitivity to soybean oil, egg lecithin, or glycerol.
• • 11. Medical substance abuse.