Efficacy and Safety of Stellate Ganglion Block With Lidocaine Combined Platelet-rich Plasma to Treat Chronic Migraine

Launched by BEIJING TIANTAN HOSPITAL · Oct 20, 2024

Keywords

ClinConnect Summary

This clinical trial is studying a new treatment for chronic migraines by combining two methods: a procedure called stellate ganglion block (SGB) with a local anesthetic called lidocaine, and a treatment using platelet-rich plasma (PRP). The goal is to find out if this combination is more effective and safe compared to using lidocaine alone for patients suffering from chronic migraines.

To participate in this trial, you need to be between 18 and 75 years old, have a body mass index (BMI) between 15 and 35, and have been diagnosed with chronic migraines that cause significant pain. Participants will receive the SGB treatment and will be monitored to see how well they respond. It's important to note that there are certain health conditions and medications that may exclude someone from joining the study, so potential participants will be carefully screened. This trial is currently recruiting, and anyone interested should consider discussing it with their doctor for more information.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Age between 18 to 75 years;
• • 2. BMI between 15 and 35 kg/m2 ;
• • 3. Diagnosed with CM in accordance with the International Classification of Headache Disorders, 3rd Edition (ICHD-3) criteria (Headache Classification Committee of the International Headache Society (IHS) The International Classification of Headache Disorders, 3rd edition. Cephalalgia. 2018 Jan;38(1):1-211);
• • 4. Visual Analogue Scale (VAS; range, 0-10; 0 = no pain and 10 = worst possible pain; higher scores indicate more severe pain) score≥7;
• • 5. Scheduled for lidocaine acting on SGB treatment for CM；
• • 6. Signed informed consent.
• Exclusion Criteria:
• • 1. Previously received SGB treatment;
• • 2. Combined with other types of headaches;
• • 3. Platelet count \<105\*109/L, use of anticoagulants or antiplatelet agent, coagulation disorders or bleeding disorders;
• • 4. Infection or mass near the puncture site;
• • 5. A history of other neurological disorders;
• • 6. A history of severe cardiopulmonary, hepatic or renal dysfunction;
• • 7. A history of psychological disorders;
• • 8. A history of narcotic drug abuse;
• • 9. Changes in neck anatomic structure caused by radiotherapy or surgery;
• • 10. A history of allergies to any research drugs;
• • 11. Pregnancy or lactation period.