Intravenous Acetaminophen for Postoperative Delirium in Older Patients Recovering From Major Noncardiac Surgery

Launched by RENJI HOSPITAL · Oct 20, 2024

Keywords

ClinConnect Summary

This clinical trial is studying whether giving intravenous acetaminophen (a common pain reliever) can help prevent delirium—a confusion and disorientation condition—after major surgery in older patients. The research will involve patients aged 65 and older who are scheduled for significant non-heart-related surgeries that require general anesthesia and are expected to last more than two hours. To participate, patients must be generally healthy and weigh more than 50 kg (about 110 pounds).

The trial is not yet recruiting participants, but if you or a family member are eligible, you can expect to receive the acetaminophen for five days after surgery to see if it helps reduce the risk of developing delirium. It's important to note that certain conditions, like pre-existing mental health issues or severe heart problems, may prevent someone from joining the study. Participants will need to give their written consent to take part. This research aims to improve recovery experiences for older patients after surgery, which can be a challenging time.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Age ≥ 65 years.
• • 2. Scheduled for non-cardiac major surgery with general anesthesia that is expected to last more than 2h.
• • 3. ASA Physical Status I-III.
• • 4. Weight \>50 kg.
• • 5. Written informed consent.
• Exclusion Criteria:
• • 1. Pre-existing neuropsychiatric diseases (Alzheimer's disease, Schizophrenia, Parkinson's Disease, Seizures, etc.).
• • 2. Pre-existing cognitive impairment (MMSE\<18).
• • 3. Preoperative delirium.
• • 4. Severe circulatory instability (preoperative left ventricular ejection fraction less than 30%, unstable angina, severe coronary artery disease, sick sinus syndrome, etc.).
• • 5. Contraindication to the acetaminophen use, including serum creatinine \> 177µmol/L or aminotransferses \> 3 times the upper limit of normal.
• • 6. Alcohol or drug abuse within a year before surgery.
• • 7. Inability to communicate because of severe visual/auditory dysfunction or language barrier.