Effect of Bupivacaine Liposomes or Bupivacaine for Femoral Triangle or Adductor Block on Analgesia After Total Knee Replacement

Launched by HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY · Oct 21, 2024

Keywords

ClinConnect Summary

This clinical trial is studying how effective a new form of pain relief called bupivacaine liposomes is compared to standard bupivacaine for patients undergoing total knee replacement surgery. The researchers want to find out if using bupivacaine liposomes can help reduce the amount of pain medication (opioids) needed in the first 72 hours after surgery and whether one specific method of delivering the anesthetic (called the femoral triangle block or adductor block) is better than the other at managing pain.

To be eligible for this study, participants must be between 18 and 80 years old and scheduled for their first knee replacement surgery. They cannot have certain health issues or conditions, such as allergies to local anesthetics or diabetes-related nerve problems. Participants will receive either the new bupivacaine liposomes or the standard bupivacaine before surgery and will be monitored for pain levels, muscle strength, and any complications in the days following the procedure. This trial aims to improve pain management after knee surgery, which is important for recovery and overall patient comfort.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Patients with ASAI-ⅲ
• • 2. Receive a unilateral initial TKA
• • 3. Age 18-80 years old -
• Exclusion Criteria:
• • 1. Bilateral TKA surgery
• • 2. TKA revision surgery
• • 3. Contraindications for nerve block and intraspinal anesthesia
• • 4. Allergies to local anesthetics
• • 5. Diabetic neuropathy
• • 6. Patients who are unable to cooperate with the evaluation
• • 7. Chronic use of opioid analgesics
• • 8. BMI≥35kg/cm2
• • 9. Cases of lumbar anesthesia failure requiring general anesthesia surgery
• • 10. Cases of nerve block failure
• • -