Effect of Adding Glycerol to Electrolyte Beverages on Fluid Balance in Healthy Euhydrated Men and Women at Rest

Launched by PEPSICO GLOBAL R&D · Oct 21, 2024

Keywords

ClinConnect Summary

This clinical trial is studying how adding glycerol, a type of sugar alcohol, to electrolyte drinks affects fluid balance in healthy men and women at rest. The researchers believe that adding glycerol will help keep the body's fluid levels balanced for a longer time compared to drinks without glycerol. They want to see if drinks with different amounts of carbohydrates (sugars) will have similar effects on fluid balance, both being better than a plain drink without any added ingredients.

To be eligible to participate, you must be between 18 and 50 years old, be generally healthy, and engage in regular physical activity. You should not be pregnant, smoke, or take certain medications that could affect the study. Participants will need to fast overnight before their visits and avoid alcohol and intense exercise for a short period before the tests. If you join, you can expect to drink the test beverages and help researchers understand how glycerol affects hydration. This is a great opportunity to contribute to research that could improve sports and hydration drinks in the future!

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Subject is male or female
• • If female, subject is not pregnant (based on self-report)
• • Subject is 18-50 years of age, inclusive Subject is at least recreationally active (engaged in light to moderate intensity, intermittent, or steady-state exercise at least 3 days per week for at least 30 min at a time)
• • Subject does not smoke (or has quit for at least 6 months)
• • Subject is not taking medication that may interfere with the study (e.g., diuretics)
• • Subject has no health conditions that would interfere with the study, As indicated on the general health questionnaire (GHQ), e.g. cardiovascular, renal, or metabolic diseases
• • Subject is not allergic to adhesives (e.g., medical tape)
• • Subject is not allergic to kiwi-strawberry flavoring
• • Subject is willing to avoid alcohol consumption 24 hours prior to visit(s)
• • Subject is willing to fast overnight (\~8-12 hours)
• • Subject is willing to refrain from vigorous exercise for 24 hours (light physical activity only)
• • Subject is willing to eat the exact same food the day prior to each visit to the laboratory
• • Able to speak, write, and read English
• • Provision of written consent to participate
• Exclusion Criteria:
• • Subject has participated in a clinical trial within the past 30 days
• • Subject has participated in any PepsiCo trial within past 6 months
• • Subject has a condition or is taking medication that the investigator believes would interfere with his/her ability to provide informed consent, comply with the study protocol, which might confound the interpretation of the study results, or put the person at undue risk
• • Subject is employed by, or has a parent, guardian, or other immediate family member employed by a company that manufactures any products that compete with any Gatorade product. If subject is unsure if a company would be considered a competitor to Gatorade, they will be asked to please let the study investigator know the name of the other company and the nature of their relationship to that company before they sign the informed consent.