Family Members At INcreased-risk for Developing Inflammatory Bowel Disease

Launched by MASSACHUSETTS GENERAL HOSPITAL · Oct 22, 2024

Keywords

ClinConnect Summary

This clinical trial is studying how certain behaviors, diets, and biological markers can help predict whether first-degree relatives of people with inflammatory bowel disease (IBD) will develop the condition themselves. IBD includes diseases like Crohn's disease and ulcerative colitis. The study will follow family members who do not currently have IBD over a period of about 10 years. Participants will be asked to fill out a questionnaire once a year and provide samples of blood, stool, and urine. Some parts of the study can be done from home, but blood samples will need to be collected at Massachusetts General Hospital.

To be eligible for this study, participants must be at least 14 years old and have at least one first-degree relative, like a parent or sibling, who has IBD. They must also be able to understand and complete the study materials. However, individuals who already have IBD or show symptoms of it will not be included in the trial. This study aims to find ways to prevent IBD in those who are at higher risk, potentially benefiting many families affected by these conditions.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Ability to give informed consent
• • Ability to complete all study visits and study-related procedures
• • Ability to understand and complete study questionnaires
• • Must have at least one first-degree relative with inflammatory bowel disease (Crohn's disease, ulcerative colitis, or IBD-unclassified)
• • Age ≥ 14
• Exclusion Criteria:
• • Individuals with existing diagnoses of inflammatory bowel disease (ulcerative colitis, Crohn's disease, or IBD-unclassified)
• • Evidence of clinical signs or symptoms of IBD, which will be identified on pre-screening interview with the study coordinator.