The REDUCE EU Study - Endobronchial Thermal Liquid Ablation (ETLA) for the Treatment of Emphysema

Launched by MORAIR MEDTECH, LLC · Oct 22, 2024

Keywords

ClinConnect Summary

The REDUCE EU Study is looking to understand if a new treatment called endobronchial thermal liquid ablation (ETLA) can help people with severe emphysema, a serious lung condition that makes it hard to breathe. This study will involve participants undergoing up to two ETLA procedures and attending several follow-up visits, both in person and online, to monitor their health and the treatment's effectiveness.

To be eligible for this trial, participants should be at least 40 years old and have been diagnosed with chronic obstructive pulmonary disease (COPD). They need to have specific lung function measurements and should not have smoked for at least three months before joining. Participants will also need to engage in regular physical activity, like walking or a pulmonary rehabilitation program. It's important to note that individuals with certain health issues, such as uncontrolled diabetes or recent serious lung infections, may not qualify for the study. If you are interested in participating, this trial could provide an opportunity to explore a new treatment option for emphysema while closely monitored by healthcare professionals.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age ≥ 40 years old
• • Diagnosis of COPD with FEV1/FVC less than 0.7 post-bronchodilation
• • Post-bronchodilator Forced Expiratory Volume (FEV1) ≥ 20% and ≤ 49% of predicted value
• • Total lung capacity (TLC) ≥ 100% predicted
• • Residual volume (RV) ≥ 175% predicted
• • 6 Minute Walk Distance (6MWD) ≥ 140 meters
• • Dyspnea scoring ≥ 1 on the modified Medical Research Council scale (mMRC)
• • Blood gas values of PCO2 ≤ 55 mmHg; PO2 ≥ 45 mmHg on room air
• • Optimized medical management (consistent with GOLD guidelines) as confirmed by the Investigator
• • Non-smoking for 3 months prior to study enrollment, as confirmed by lab testing
• • Participant must engages in physical exercise beyond activities of daily living (i.e., a walking program, pulmonary rehabilitation) on n a regular basis for more than 6 weeks prior to enrollment and agree to continue the activity throughout study participation
• • Participant must live within approximately 1 hour of the study hospital, or live within 1 hour of adequate regional care, or be willing to remain in the hospital for at least five days post-procedure
• • Vaccinated for COVID-19, pneumococcus, and influenza (per European Union and Member State guidelines) or documented clinical intolerance or documented patient refusal
• • Cognitively able to provide written informed consent and willing to comply with study requirements
• • Severe emphysematous lung subsegments eligible for ETLA treatment
• Exclusion Criteria:
• • Body mass index (BMI) \< 16 kg/m\^2 or ≥ 33 kg/m\^2
• • DLCO \< 20% predicted
• • Chronic bronchitis as defined by cough and sputum production for at least 3 months per year for two consecutive years, in the absence of other conditions that can explain these symptoms
• • 75ml or greater sputum production per day most days of the week
• • Greater than two hospitalizations for COPD exacerbations and/or pneumonia in the 12 months prior to enrollment
• • Diagnosis of asthma that is confirmed according to the Global Initiative for Asthma (GINA) guidelines
• • Prior lung volume reduction via endobronchial valves(s), coil(s), vapor and/or polymer. Patients whose valves have been removed \> 3 months previously can be treated if a baseline bronchoscopy reveals no airway obstruction or obvious tissue granulation and the reason for valve removal was not for complications e.g., Pneumonia, severe exacerbation, or pneumothorax.
• • Pulmonary hypertension
• • Alpha-1 antitrypsin deficiency
• • Uncontrolled diabetes mellitus
• • Prior heart or lung transplant
• • Myocardial infarction or stroke within the 12 months of enrollment
• • Diagnosis of heart failure
• • Heart failure requiring hospitalization, within 6 months prior to enrollment
• • History of bleeding disorders or enhanced predisposition to bleeding
• • History of severe/massive hemoptysis defined as \>200ml of blood loss in \< 24 hours
• • Unable to discontinue anti-coagulants or platelet inhibitors (acetylsalicylic acid \[ASA\]and non-ASA, including low dose) for at least 7 days prior to each procedure (or as per physician discretion based on the specific agent) and for at least 6 weeks after each procedure
• • Daily systemic steroids equivalent to \> 15mg prednisolone
• • Immunosuppressive drugs, such as for the treatment of cancer, autoimmune disease, or prevention of tissue/organ rejection
• • Pregnant, lactating, or women of childbearing potential that plan to become pregnant within the study duration
• • Currently enrolled in another trial studying an experimental treatment
• • Any disease or condition likely to limit survival to less than one year
• • Concomitant illnesses or medications that may pose a significant increased risk for complications following treatment with ETLA
• • Any condition that would interfere with evaluation or completion of the study including study assessments and procedures, including bronchoscopy.
• • Active aspergillus infection
• • Clinically significant bronchiectasis as determined by the Investigator
• • Radiological evidence of bronchiectasis in target region(s) and/or cystic radiological bronchiectasis in any region of the lungs
• • Clinically significant pulmonary fibrosis
• • Lung nodule not proven stable unless proven to have benign pathology
• • Large bulla (defined as \> 1/3 volume of a lung)
• • Prior Lung Volume Reduction Surgery (LVRS), bullectomy, or lobectomy
• • The remaining lung tissue NOT targeted for ETLA treatment is too highly diseased
• • Active respiratory infection or recent respiratory infection with resolution \< 4 weeks prior to screening or procedure
• • Recent COPD exacerbation within \< 6 weeks prior to screening or procedure