Effects of an Exercise Program in Women Over 60 yr. With HFpEF and Sarcopenia on Functional Capacity and Quality of Life

Launched by FUNDACIÓN PARA LA INVESTIGACIÓN DEL HOSPITAL CLÍNICO DE VALENCIA · Oct 22, 2024

Keywords

ClinConnect Summary

This clinical trial is studying the effects of a 12-week exercise program on women over 60 years old who have heart failure with preserved ejection fraction (HFpEF) and sarcopenia, which is a condition that causes muscle loss. The trial aims to see if combining aerobic exercises (like walking or cycling) with strength training (like lifting weights) can improve these women's physical ability and quality of life. Participants will be randomly divided into two groups: one will receive standard medical care, while the other will take part in the supervised exercise program. After 12 weeks, researchers will evaluate the results by measuring how well participants can perform physical activities.

To be eligible for this trial, women must be at least 60 years old, diagnosed with HFpEF, and show signs of muscle loss. They should also be stable and able to perform daily activities, as indicated by their heart failure classification. Participants will need to agree to take part in the study and complete some initial tests to ensure they are suitable for the exercise program. This study is not yet recruiting participants, but it aims to help improve treatment options for older women facing these health challenges.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • Patients diagnosed with heart failure with preserved ejection fraction according to 2021 ESC guidelines for Heart Failure, with N-terminal pro-B-type natriuretic peptide (NT-proBNP) \>125 pg/mL, inthe last month.
• • Stable symptomatic heart failure patients (New York Heart Association functional class II-III) during the last month.
• • Age ≥ 60 years old.
• • The participant is willing to give informed consent to participate in the study.
• • SARC-F score ≥4 points.
• Exclusion Criteria:
• • Inability to perform a valid baseline cardiopulmonary exercise test.
• • Cardiac pacemaker.
• • Significant primary moderate-to-severe valve disease.
• • Effort angina or signs of ischemia during CPET.
• • Primary cardiomyopathies.
• • Cardiac transplantation.
• • Any other comorbidity with a life expectancy of less than one year.