Amino Acid Loss During Continuous Renal Replacement Therapy

Launched by MEDICAL UNIVERSITY OF VIENNA · Oct 24, 2024

Keywords

ClinConnect Summary

This clinical trial is studying how amino acids, which are important building blocks for our body, are lost during a specific treatment called continuous renal replacement therapy (CRRT). This treatment is often used for patients in the intensive care unit (ICU) who have kidney failure or renal insufficiency. The researchers want to find out how much amino acid is lost during the therapy and how the levels of these amino acids in the blood change over time in patients receiving CRRT compared to those who are not.

To participate in this study, you need to be at least 18 years old and currently recovering in the ICU after surgery. You should also be receiving nutrition either through a feeding tube or intravenously. The study is open to all genders and aims to include patients who are undergoing CRRT as well as those who are not receiving any kidney replacement therapy. If you join, you can expect the team to regularly measure the levels of amino acids in your blood and in the fluid collected during your treatment. This information can help improve the care of future patients with kidney issues.

Gender

ALL

Eligibility criteria

• Inclusion criteria:
• • Postoperative ICU patients
• • Age ≥ 18 years
• • Patients on enteral or/and parenteral nutrition given according to internal standard operating procedure
• A) CRRT group:
• • - CRRT treatment planned; all types of CRRT (continuous veno-venous hemodialysis (CVVHD), continuous veno-venous hemodiafiltration (CVVHDF), continuous veno-venous hemofiltration (CVVH))
• B)Non-CRRT group:
• • no current or previous (\<30 days) continuous or intermittent RRT
• • no chronic kidney disease stage G3-G5
• Exclusion criteria:
• • Preoperative intensive care patients
• • Patients with liver cirrhosis stage 1-3 according to the Child-Pugh classification
• • Patients with acute liver failure