Evaluation of Exercise Testing and Physical Activity in Children and Adolescents Living With Inherited Arrhythmias
Launched by ROYAL BROMPTON & HAREFIELD NHS FOUNDATION TRUST · Oct 24, 2024
Trial Information
Current as of July 25, 2025
Recruiting
Keywords
ClinConnect Summary
This clinical trial is studying how well exercise testing can help us understand physical activity in children and teenagers who have inherited heart conditions called long QT syndrome and catecholaminergic polymorphic ventricular tachycardia. The main goal is to see if the maximum heart rate measured during a controlled exercise test on a treadmill matches what these kids experience during their everyday activities. By doing this, researchers hope to find better ways to monitor and support their heart health.
To participate, children aged 6 to 16 years who have been diagnosed with one of these heart conditions, as well as their healthy siblings, can take part. Participants will perform a treadmill exercise test and wear a monitor for two weeks to track their daily activity and heart rate. At the end of this period, they will fill out a questionnaire about their physical activity. It’s important to note that the trial is not yet recruiting participants, and it currently only includes children who are able to run on a treadmill and understand English.
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Affected cohort
- • Male and female children
- • Aged 6-16 years
- • Diagnosed with long QT syndrome or catecholaminergic polymorphic ventricular tachycardia
- • Treated with beta-blocker and/or sodium channel blockade
- • Able to complete a treadmill ETT
- • Healthy cohort
- • Male and female children
- • Aged 6-16 years
- • Siblings of affected children (gene negative)
- • Undergoing IAS screening
- • Able to complete a treadmill ETT
- Exclusion Criteria:
- • Children aged less than 6 years
- • Adults, 17 years of age and above
- • Unable to run on an exercise treadmill due to physical limitations.
- • Individuals unable to speak or understand English, due to no translation service available.
- • Pregnancy
About Royal Brompton & Harefield Nhs Foundation Trust
Royal Brompton & Harefield NHS Foundation Trust is a leading specialist healthcare provider in the United Kingdom, renowned for its expertise in cardiothoracic medicine and respiratory care. Committed to advancing clinical research and improving patient outcomes, the Trust conducts a diverse range of clinical trials aimed at exploring innovative treatments and therapies. With a multidisciplinary team of clinicians and researchers, the Foundation Trust fosters a collaborative environment that prioritizes patient safety and ethical standards, contributing significantly to the global body of medical knowledge and enhancing the quality of care for patients with complex health conditions.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
London, , United Kingdom
London Borough Of Sutton, , United Kingdom
Patients applied
Trial Officials
Catherine E Renwick
Principal Investigator
Royal Brompton & Harefield NHS Foundation Trust
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported