Cardiac RadiothErapy For hEart faiLure

Launched by UNIVERSITAIRE ZIEKENHUIZEN KU LEUVEN · Oct 25, 2024

Keywords

ClinConnect Summary

This clinical trial, called Cardiac Radiotherapy for Heart Failure, is studying whether a special type of radiation treatment can help patients with advanced heart failure feel better and improve their heart function. Specifically, the researchers are looking at a single low dose of radiation given to the whole heart to see if it can improve a key measurement of heart health called left ventricular ejection fraction (LVEF) by at least 5%. This trial is currently recruiting participants aged 18 and older who have advanced heart failure symptoms and have been stable on their heart medications for the last six months.

To be eligible for this study, patients should have certain types of heart failure, like ischemic or dilated cardiomyopathy, and their heart function should be quite low, with LVEF of 35% or less. Participants will receive the radiation treatment and will be monitored for its effects on their heart function, overall health, and quality of life. It’s important to know that some people may not be eligible for this trial, such as those considering heart transplants or those who have had previous radiation affecting the heart. If you or a loved one is interested, it’s a good idea to discuss this with a healthcare provider to see if it might be a suitable option.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patient ≥ 18 years
• • Advanced refractory HF NYHA class II, III or IV
• • Stable HF for the last 6 months with maximal guideline-directed HF therapy
• • Ischemic or dilated cardiomyopathy
• • LVEF at baseline ≤ 35%
• • Ability to give a written informed consent and willingness to return for follow-up
• Exclusion Criteria:
• • Eligible or in consideration for heart transplantation
• • Pregnancy or breastfeeding
• • Previous radiotherapy with cardiac involvement
• • Any condition that is deemed a contraindication in the judgment of the investigators